Osteocyte Alterations Induce Osteoclastogenesis in an In Vitro Model of Gaucher Disease

Gaucher disease (GD) is caused by mutations in the glucosylceramidase β (GBA 1) gene that confer a deficient level of activity of glucocerebrosidase (GCase). This deficiency leads to the accumulation of the glycolipid glucocerebroside in the lysosomes of cells, mainly in the monocyte/macrophage line...

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Detalles Bibliográficos
Autores principales: Bondar, Constanza, Ormazabal, Maximiliano, Crivaro, Andrea, Ferreyra-Compagnucci, Malena, Delpino, María Victoria, Rozenfeld, Paula Adriana, Mucci, Juan Marcos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297746/
https://www.ncbi.nlm.nih.gov/pubmed/28098793
http://dx.doi.org/10.3390/ijms18010112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297746/
https://www.ncbi.nlm.nih.gov/pubmed/28098793
http://dx.doi.org/10.3390/ijms18010112

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