Hydroxypyridinone Chelators: From Iron Scavenging to Radiopharmaceuticals for PET Imaging with Gallium-68

Derivatives of 3,4-hydroxypyridinones have been extensively studied for in vivo Fe(3+) sequestration. Deferiprone, a 1,2-dimethyl-3,4-hydroxypyridinone, is now routinely used for clinical treatment of iron overload disease. Hexadentate tris(3,4-hydroxypyridinone) ligands (THP) complex Fe(3+) at very...

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Detalles Bibliográficos
Autores principales: Cusnir, Ruslan, Imberti, Cinzia, Hider, Robert C., Blower, Philip J., Ma, Michelle T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297750/
https://www.ncbi.nlm.nih.gov/pubmed/28075350
http://dx.doi.org/10.3390/ijms18010116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297750/
https://www.ncbi.nlm.nih.gov/pubmed/28075350
http://dx.doi.org/10.3390/ijms18010116

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