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The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles
Nanoparticles (NPs) possess unique physical and chemical properties that make them appropriate for various applications. The structural alteration of metallic NPs leads to different biological functions, specifically resulting in different potentials for the generation of reactive oxygen species (RO...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297754/ https://www.ncbi.nlm.nih.gov/pubmed/28075405 http://dx.doi.org/10.3390/ijms18010120 |
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author | Abdal Dayem, Ahmed Hossain, Mohammed Kawser Lee, Soo Bin Kim, Kyeongseok Saha, Subbroto Kumar Yang, Gwang-Mo Choi, Hye Yeon Cho, Ssang-Goo |
author_facet | Abdal Dayem, Ahmed Hossain, Mohammed Kawser Lee, Soo Bin Kim, Kyeongseok Saha, Subbroto Kumar Yang, Gwang-Mo Choi, Hye Yeon Cho, Ssang-Goo |
author_sort | Abdal Dayem, Ahmed |
collection | PubMed |
description | Nanoparticles (NPs) possess unique physical and chemical properties that make them appropriate for various applications. The structural alteration of metallic NPs leads to different biological functions, specifically resulting in different potentials for the generation of reactive oxygen species (ROS). The amount of ROS produced by metallic NPs correlates with particle size, shape, surface area, and chemistry. ROS possess multiple functions in cellular biology, with ROS generation a key factor in metallic NP-induced toxicity, as well as modulation of cellular signaling involved in cell death, proliferation, and differentiation. In this review, we briefly explained NP classes and their biomedical applications and describe the sources and roles of ROS in NP-related biological functions in vitro and in vivo. Furthermore, we also described the roles of metal NP-induced ROS generation in stem cell biology. Although the roles of ROS in metallic NP-related biological functions requires further investigation, modulation and characterization of metallic NP-induced ROS production are promising in the application of metallic NPs in the areas of regenerative medicine and medical devices. |
format | Online Article Text |
id | pubmed-5297754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-52977542017-02-10 The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles Abdal Dayem, Ahmed Hossain, Mohammed Kawser Lee, Soo Bin Kim, Kyeongseok Saha, Subbroto Kumar Yang, Gwang-Mo Choi, Hye Yeon Cho, Ssang-Goo Int J Mol Sci Review Nanoparticles (NPs) possess unique physical and chemical properties that make them appropriate for various applications. The structural alteration of metallic NPs leads to different biological functions, specifically resulting in different potentials for the generation of reactive oxygen species (ROS). The amount of ROS produced by metallic NPs correlates with particle size, shape, surface area, and chemistry. ROS possess multiple functions in cellular biology, with ROS generation a key factor in metallic NP-induced toxicity, as well as modulation of cellular signaling involved in cell death, proliferation, and differentiation. In this review, we briefly explained NP classes and their biomedical applications and describe the sources and roles of ROS in NP-related biological functions in vitro and in vivo. Furthermore, we also described the roles of metal NP-induced ROS generation in stem cell biology. Although the roles of ROS in metallic NP-related biological functions requires further investigation, modulation and characterization of metallic NP-induced ROS production are promising in the application of metallic NPs in the areas of regenerative medicine and medical devices. MDPI 2017-01-10 /pmc/articles/PMC5297754/ /pubmed/28075405 http://dx.doi.org/10.3390/ijms18010120 Text en © 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Abdal Dayem, Ahmed Hossain, Mohammed Kawser Lee, Soo Bin Kim, Kyeongseok Saha, Subbroto Kumar Yang, Gwang-Mo Choi, Hye Yeon Cho, Ssang-Goo The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles |
title | The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles |
title_full | The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles |
title_fullStr | The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles |
title_full_unstemmed | The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles |
title_short | The Role of Reactive Oxygen Species (ROS) in the Biological Activities of Metallic Nanoparticles |
title_sort | role of reactive oxygen species (ros) in the biological activities of metallic nanoparticles |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297754/ https://www.ncbi.nlm.nih.gov/pubmed/28075405 http://dx.doi.org/10.3390/ijms18010120 |
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