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Perioperative Search for Circulating Tumor Cells in Patients Undergoing Prostate Brachytherapy for Clinically Nonmetastatic Prostate Cancer

Despite the absence of local prostate cancer recurrence, some patients develop distant metastases after prostate brachytherapy. We evaluate whether prostate brachytherapy procedures have a potential risk for hematogenous spillage of prostate cancer cells. Fifty-nine patients who were undergoing high...

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Autores principales: Tsumura, Hideyasu, Satoh, Takefumi, Ishiyama, Hiromichi, Tabata, Ken-ichi, Takenaka, Kouji, Sekiguchi, Akane, Nakamura, Masaki, Kitano, Masashi, Hayakawa, Kazushige, Iwamura, Masatsugu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297762/
https://www.ncbi.nlm.nih.gov/pubmed/28085051
http://dx.doi.org/10.3390/ijms18010128
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author Tsumura, Hideyasu
Satoh, Takefumi
Ishiyama, Hiromichi
Tabata, Ken-ichi
Takenaka, Kouji
Sekiguchi, Akane
Nakamura, Masaki
Kitano, Masashi
Hayakawa, Kazushige
Iwamura, Masatsugu
author_facet Tsumura, Hideyasu
Satoh, Takefumi
Ishiyama, Hiromichi
Tabata, Ken-ichi
Takenaka, Kouji
Sekiguchi, Akane
Nakamura, Masaki
Kitano, Masashi
Hayakawa, Kazushige
Iwamura, Masatsugu
author_sort Tsumura, Hideyasu
collection PubMed
description Despite the absence of local prostate cancer recurrence, some patients develop distant metastases after prostate brachytherapy. We evaluate whether prostate brachytherapy procedures have a potential risk for hematogenous spillage of prostate cancer cells. Fifty-nine patients who were undergoing high-dose-rate (HDR) or low-dose-rate (LDR) brachytherapy participated in this prospective study. Thirty patients with high-risk or locally advanced cancer were treated with HDR brachytherapy after neoadjuvant androgen deprivation therapy (ADT). Twenty-nine patients with clinically localized cancer were treated with LDR brachytherapy without neoadjuvant ADT. Samples of peripheral blood were drawn in the operating room before insertion of needles (preoperative) and again immediately after the surgical manipulation (intraoperative). Blood samples of 7.5 mL were analyzed for circulating tumor cells (CTCs) using the CellSearch System. While no preoperative samples showed CTCs (0%), they were detected in intraoperative samples in 7 of the 59 patients (11.8%; preoperative vs. intraoperative, p = 0.012). Positive CTC status did not correlate with perioperative variables, including prostate-specific antigen (PSA) at diagnosis, use of neoadjuvant ADT, type of brachytherapy, Gleason score, and biopsy positive core rate. We detected CTCs from samples immediately after the surgical manipulation. Further study is needed to evaluate whether those CTCs actually can survive and proliferate at distant sites.
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spelling pubmed-52977622017-02-10 Perioperative Search for Circulating Tumor Cells in Patients Undergoing Prostate Brachytherapy for Clinically Nonmetastatic Prostate Cancer Tsumura, Hideyasu Satoh, Takefumi Ishiyama, Hiromichi Tabata, Ken-ichi Takenaka, Kouji Sekiguchi, Akane Nakamura, Masaki Kitano, Masashi Hayakawa, Kazushige Iwamura, Masatsugu Int J Mol Sci Article Despite the absence of local prostate cancer recurrence, some patients develop distant metastases after prostate brachytherapy. We evaluate whether prostate brachytherapy procedures have a potential risk for hematogenous spillage of prostate cancer cells. Fifty-nine patients who were undergoing high-dose-rate (HDR) or low-dose-rate (LDR) brachytherapy participated in this prospective study. Thirty patients with high-risk or locally advanced cancer were treated with HDR brachytherapy after neoadjuvant androgen deprivation therapy (ADT). Twenty-nine patients with clinically localized cancer were treated with LDR brachytherapy without neoadjuvant ADT. Samples of peripheral blood were drawn in the operating room before insertion of needles (preoperative) and again immediately after the surgical manipulation (intraoperative). Blood samples of 7.5 mL were analyzed for circulating tumor cells (CTCs) using the CellSearch System. While no preoperative samples showed CTCs (0%), they were detected in intraoperative samples in 7 of the 59 patients (11.8%; preoperative vs. intraoperative, p = 0.012). Positive CTC status did not correlate with perioperative variables, including prostate-specific antigen (PSA) at diagnosis, use of neoadjuvant ADT, type of brachytherapy, Gleason score, and biopsy positive core rate. We detected CTCs from samples immediately after the surgical manipulation. Further study is needed to evaluate whether those CTCs actually can survive and proliferate at distant sites. MDPI 2017-01-11 /pmc/articles/PMC5297762/ /pubmed/28085051 http://dx.doi.org/10.3390/ijms18010128 Text en © 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Tsumura, Hideyasu
Satoh, Takefumi
Ishiyama, Hiromichi
Tabata, Ken-ichi
Takenaka, Kouji
Sekiguchi, Akane
Nakamura, Masaki
Kitano, Masashi
Hayakawa, Kazushige
Iwamura, Masatsugu
Perioperative Search for Circulating Tumor Cells in Patients Undergoing Prostate Brachytherapy for Clinically Nonmetastatic Prostate Cancer
title Perioperative Search for Circulating Tumor Cells in Patients Undergoing Prostate Brachytherapy for Clinically Nonmetastatic Prostate Cancer
title_full Perioperative Search for Circulating Tumor Cells in Patients Undergoing Prostate Brachytherapy for Clinically Nonmetastatic Prostate Cancer
title_fullStr Perioperative Search for Circulating Tumor Cells in Patients Undergoing Prostate Brachytherapy for Clinically Nonmetastatic Prostate Cancer
title_full_unstemmed Perioperative Search for Circulating Tumor Cells in Patients Undergoing Prostate Brachytherapy for Clinically Nonmetastatic Prostate Cancer
title_short Perioperative Search for Circulating Tumor Cells in Patients Undergoing Prostate Brachytherapy for Clinically Nonmetastatic Prostate Cancer
title_sort perioperative search for circulating tumor cells in patients undergoing prostate brachytherapy for clinically nonmetastatic prostate cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297762/
https://www.ncbi.nlm.nih.gov/pubmed/28085051
http://dx.doi.org/10.3390/ijms18010128
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