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Multiple Activities of Punica granatum Linne against Acne Vulgaris
Acne is a common skin condition with sebum overproduction, hyperkeratosis, Propionibacterium acnes (P. acnes) and Staphylococcus aureus, and inflammation. Punica granatum (pomegranate) is well-known for its anti-inflammatory effects; however, few studies have discussed the anti-acne effects of pomeg...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297774/ https://www.ncbi.nlm.nih.gov/pubmed/28085116 http://dx.doi.org/10.3390/ijms18010141 |
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author | Lee, Chia-Jung Chen, Lih-Geeng Liang, Wen-Li Wang, Ching-Chiung |
author_facet | Lee, Chia-Jung Chen, Lih-Geeng Liang, Wen-Li Wang, Ching-Chiung |
author_sort | Lee, Chia-Jung |
collection | PubMed |
description | Acne is a common skin condition with sebum overproduction, hyperkeratosis, Propionibacterium acnes (P. acnes) and Staphylococcus aureus, and inflammation. Punica granatum (pomegranate) is well-known for its anti-inflammatory effects; however, few studies have discussed the anti-acne effects of pomegranate. In this study, we found that pomegranate extract (PG-E) significantly reduced P. acnes-induced edema in Wistar rat ears. Therefore, an evaluation platform using multiple pathogenic mechanisms of acne was established to explore the anti-acne effects of pomegranate. Results showed that PG-E inhibited bacterial growth and lipase activity. Through a bioguided-fractionation-isolation system, four hydrolysable tannins, punicalagin (1), punicalin (2), strictinin A (3), and granatin B (4), were isolated. Compounds 1 and 2 had greater anti-bacterial activities and anti-testosterone-induced HaCaT proliferative effects than the others. Compounds 1, 3, and 4 displayed lipase inhibitory effects. Compound 4 decreased cyclooxygenase-2 expression and downregulated prostaglandin E(2) production in heat-killed P. acnes-treated RAW 246.7 cells. In conclusion, PG-E is abundant in hydrolysable tannins that display multiple anti-acne capacities, including anti-bacterial, anti-lipase, anti-keratinocyte proliferation, and anti-inflammatory actions. Hence, PG-E has great potential in the application of anti-acne and skin-care products, and punicalagin (1), the most effective component in PG-E, can be employed as a quality control marker. |
format | Online Article Text |
id | pubmed-5297774 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-52977742017-02-10 Multiple Activities of Punica granatum Linne against Acne Vulgaris Lee, Chia-Jung Chen, Lih-Geeng Liang, Wen-Li Wang, Ching-Chiung Int J Mol Sci Article Acne is a common skin condition with sebum overproduction, hyperkeratosis, Propionibacterium acnes (P. acnes) and Staphylococcus aureus, and inflammation. Punica granatum (pomegranate) is well-known for its anti-inflammatory effects; however, few studies have discussed the anti-acne effects of pomegranate. In this study, we found that pomegranate extract (PG-E) significantly reduced P. acnes-induced edema in Wistar rat ears. Therefore, an evaluation platform using multiple pathogenic mechanisms of acne was established to explore the anti-acne effects of pomegranate. Results showed that PG-E inhibited bacterial growth and lipase activity. Through a bioguided-fractionation-isolation system, four hydrolysable tannins, punicalagin (1), punicalin (2), strictinin A (3), and granatin B (4), were isolated. Compounds 1 and 2 had greater anti-bacterial activities and anti-testosterone-induced HaCaT proliferative effects than the others. Compounds 1, 3, and 4 displayed lipase inhibitory effects. Compound 4 decreased cyclooxygenase-2 expression and downregulated prostaglandin E(2) production in heat-killed P. acnes-treated RAW 246.7 cells. In conclusion, PG-E is abundant in hydrolysable tannins that display multiple anti-acne capacities, including anti-bacterial, anti-lipase, anti-keratinocyte proliferation, and anti-inflammatory actions. Hence, PG-E has great potential in the application of anti-acne and skin-care products, and punicalagin (1), the most effective component in PG-E, can be employed as a quality control marker. MDPI 2017-01-12 /pmc/articles/PMC5297774/ /pubmed/28085116 http://dx.doi.org/10.3390/ijms18010141 Text en © 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lee, Chia-Jung Chen, Lih-Geeng Liang, Wen-Li Wang, Ching-Chiung Multiple Activities of Punica granatum Linne against Acne Vulgaris |
title | Multiple Activities of Punica granatum Linne against Acne Vulgaris |
title_full | Multiple Activities of Punica granatum Linne against Acne Vulgaris |
title_fullStr | Multiple Activities of Punica granatum Linne against Acne Vulgaris |
title_full_unstemmed | Multiple Activities of Punica granatum Linne against Acne Vulgaris |
title_short | Multiple Activities of Punica granatum Linne against Acne Vulgaris |
title_sort | multiple activities of punica granatum linne against acne vulgaris |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297774/ https://www.ncbi.nlm.nih.gov/pubmed/28085116 http://dx.doi.org/10.3390/ijms18010141 |
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