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Multiple Activities of Punica granatum Linne against Acne Vulgaris

Acne is a common skin condition with sebum overproduction, hyperkeratosis, Propionibacterium acnes (P. acnes) and Staphylococcus aureus, and inflammation. Punica granatum (pomegranate) is well-known for its anti-inflammatory effects; however, few studies have discussed the anti-acne effects of pomeg...

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Autores principales: Lee, Chia-Jung, Chen, Lih-Geeng, Liang, Wen-Li, Wang, Ching-Chiung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297774/
https://www.ncbi.nlm.nih.gov/pubmed/28085116
http://dx.doi.org/10.3390/ijms18010141
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author Lee, Chia-Jung
Chen, Lih-Geeng
Liang, Wen-Li
Wang, Ching-Chiung
author_facet Lee, Chia-Jung
Chen, Lih-Geeng
Liang, Wen-Li
Wang, Ching-Chiung
author_sort Lee, Chia-Jung
collection PubMed
description Acne is a common skin condition with sebum overproduction, hyperkeratosis, Propionibacterium acnes (P. acnes) and Staphylococcus aureus, and inflammation. Punica granatum (pomegranate) is well-known for its anti-inflammatory effects; however, few studies have discussed the anti-acne effects of pomegranate. In this study, we found that pomegranate extract (PG-E) significantly reduced P. acnes-induced edema in Wistar rat ears. Therefore, an evaluation platform using multiple pathogenic mechanisms of acne was established to explore the anti-acne effects of pomegranate. Results showed that PG-E inhibited bacterial growth and lipase activity. Through a bioguided-fractionation-isolation system, four hydrolysable tannins, punicalagin (1), punicalin (2), strictinin A (3), and granatin B (4), were isolated. Compounds 1 and 2 had greater anti-bacterial activities and anti-testosterone-induced HaCaT proliferative effects than the others. Compounds 1, 3, and 4 displayed lipase inhibitory effects. Compound 4 decreased cyclooxygenase-2 expression and downregulated prostaglandin E(2) production in heat-killed P. acnes-treated RAW 246.7 cells. In conclusion, PG-E is abundant in hydrolysable tannins that display multiple anti-acne capacities, including anti-bacterial, anti-lipase, anti-keratinocyte proliferation, and anti-inflammatory actions. Hence, PG-E has great potential in the application of anti-acne and skin-care products, and punicalagin (1), the most effective component in PG-E, can be employed as a quality control marker.
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spelling pubmed-52977742017-02-10 Multiple Activities of Punica granatum Linne against Acne Vulgaris Lee, Chia-Jung Chen, Lih-Geeng Liang, Wen-Li Wang, Ching-Chiung Int J Mol Sci Article Acne is a common skin condition with sebum overproduction, hyperkeratosis, Propionibacterium acnes (P. acnes) and Staphylococcus aureus, and inflammation. Punica granatum (pomegranate) is well-known for its anti-inflammatory effects; however, few studies have discussed the anti-acne effects of pomegranate. In this study, we found that pomegranate extract (PG-E) significantly reduced P. acnes-induced edema in Wistar rat ears. Therefore, an evaluation platform using multiple pathogenic mechanisms of acne was established to explore the anti-acne effects of pomegranate. Results showed that PG-E inhibited bacterial growth and lipase activity. Through a bioguided-fractionation-isolation system, four hydrolysable tannins, punicalagin (1), punicalin (2), strictinin A (3), and granatin B (4), were isolated. Compounds 1 and 2 had greater anti-bacterial activities and anti-testosterone-induced HaCaT proliferative effects than the others. Compounds 1, 3, and 4 displayed lipase inhibitory effects. Compound 4 decreased cyclooxygenase-2 expression and downregulated prostaglandin E(2) production in heat-killed P. acnes-treated RAW 246.7 cells. In conclusion, PG-E is abundant in hydrolysable tannins that display multiple anti-acne capacities, including anti-bacterial, anti-lipase, anti-keratinocyte proliferation, and anti-inflammatory actions. Hence, PG-E has great potential in the application of anti-acne and skin-care products, and punicalagin (1), the most effective component in PG-E, can be employed as a quality control marker. MDPI 2017-01-12 /pmc/articles/PMC5297774/ /pubmed/28085116 http://dx.doi.org/10.3390/ijms18010141 Text en © 2017 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Chia-Jung
Chen, Lih-Geeng
Liang, Wen-Li
Wang, Ching-Chiung
Multiple Activities of Punica granatum Linne against Acne Vulgaris
title Multiple Activities of Punica granatum Linne against Acne Vulgaris
title_full Multiple Activities of Punica granatum Linne against Acne Vulgaris
title_fullStr Multiple Activities of Punica granatum Linne against Acne Vulgaris
title_full_unstemmed Multiple Activities of Punica granatum Linne against Acne Vulgaris
title_short Multiple Activities of Punica granatum Linne against Acne Vulgaris
title_sort multiple activities of punica granatum linne against acne vulgaris
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297774/
https://www.ncbi.nlm.nih.gov/pubmed/28085116
http://dx.doi.org/10.3390/ijms18010141
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