Cargando…

Single shot three‐dimensional pulse sequence for hyperpolarized (13)C MRI

PURPOSE: Metabolic imaging with hyperpolarized (13)C‐labeled cell substrates is a promising technique for imaging tissue metabolism in vivo. However, the transient nature of the hyperpolarization, and its depletion following excitation, limits the imaging time and the number of excitation pulses tha...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Jiazheng, Wright, Alan J., Hu, De‐en, Hesketh, Richard, Brindle, Kevin M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297976/
https://www.ncbi.nlm.nih.gov/pubmed/26916384
http://dx.doi.org/10.1002/mrm.26168
_version_ 1782505813733015552
author Wang, Jiazheng
Wright, Alan J.
Hu, De‐en
Hesketh, Richard
Brindle, Kevin M.
author_facet Wang, Jiazheng
Wright, Alan J.
Hu, De‐en
Hesketh, Richard
Brindle, Kevin M.
author_sort Wang, Jiazheng
collection PubMed
description PURPOSE: Metabolic imaging with hyperpolarized (13)C‐labeled cell substrates is a promising technique for imaging tissue metabolism in vivo. However, the transient nature of the hyperpolarization, and its depletion following excitation, limits the imaging time and the number of excitation pulses that can be used. We describe here a single‐shot three‐dimensional (3D) imaging sequence and demonstrate its capability to generate (13)C MR images in tumor‐bearing mice injected with hyperpolarized [1‐(13)C]pyruvate. METHODS: The pulse sequence acquires a stack‐of‐spirals at two spin echoes after a single excitation pulse and encodes the kz‐dimension in an interleaved manner to enhance robustness to B(0) inhomogeneity. Spectral‐spatial pulses are used to acquire dynamic 3D images from selected hyperpolarized (13)C‐labeled metabolites. RESULTS: A nominal spatial/temporal resolution of 1.25 × 1.25 × 2.5 mm(3) × 2 s was achieved in tumor images of hyperpolarized [1‐(13)C]pyruvate and [1‐(13)C]lactate acquired in vivo. Higher resolution in the z‐direction, with a different k‐space trajectory, was demonstrated in measurements on a thermally polarized [1‐(13)C]lactate phantom. CONCLUSION: The pulse sequence is capable of imaging hyperpolarized (13)C‐labeled substrates at relatively high spatial and temporal resolutions and is robust to moderate system imperfections. Magn Reson Med 77:740–752, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
format Online
Article
Text
id pubmed-5297976
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-52979762017-02-22 Single shot three‐dimensional pulse sequence for hyperpolarized (13)C MRI Wang, Jiazheng Wright, Alan J. Hu, De‐en Hesketh, Richard Brindle, Kevin M. Magn Reson Med Imaging Methodology—Full Papers PURPOSE: Metabolic imaging with hyperpolarized (13)C‐labeled cell substrates is a promising technique for imaging tissue metabolism in vivo. However, the transient nature of the hyperpolarization, and its depletion following excitation, limits the imaging time and the number of excitation pulses that can be used. We describe here a single‐shot three‐dimensional (3D) imaging sequence and demonstrate its capability to generate (13)C MR images in tumor‐bearing mice injected with hyperpolarized [1‐(13)C]pyruvate. METHODS: The pulse sequence acquires a stack‐of‐spirals at two spin echoes after a single excitation pulse and encodes the kz‐dimension in an interleaved manner to enhance robustness to B(0) inhomogeneity. Spectral‐spatial pulses are used to acquire dynamic 3D images from selected hyperpolarized (13)C‐labeled metabolites. RESULTS: A nominal spatial/temporal resolution of 1.25 × 1.25 × 2.5 mm(3) × 2 s was achieved in tumor images of hyperpolarized [1‐(13)C]pyruvate and [1‐(13)C]lactate acquired in vivo. Higher resolution in the z‐direction, with a different k‐space trajectory, was demonstrated in measurements on a thermally polarized [1‐(13)C]lactate phantom. CONCLUSION: The pulse sequence is capable of imaging hyperpolarized (13)C‐labeled substrates at relatively high spatial and temporal resolutions and is robust to moderate system imperfections. Magn Reson Med 77:740–752, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. John Wiley and Sons Inc. 2016-02-24 2017-02 /pmc/articles/PMC5297976/ /pubmed/26916384 http://dx.doi.org/10.1002/mrm.26168 Text en © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Imaging Methodology—Full Papers
Wang, Jiazheng
Wright, Alan J.
Hu, De‐en
Hesketh, Richard
Brindle, Kevin M.
Single shot three‐dimensional pulse sequence for hyperpolarized (13)C MRI
title Single shot three‐dimensional pulse sequence for hyperpolarized (13)C MRI
title_full Single shot three‐dimensional pulse sequence for hyperpolarized (13)C MRI
title_fullStr Single shot three‐dimensional pulse sequence for hyperpolarized (13)C MRI
title_full_unstemmed Single shot three‐dimensional pulse sequence for hyperpolarized (13)C MRI
title_short Single shot three‐dimensional pulse sequence for hyperpolarized (13)C MRI
title_sort single shot three‐dimensional pulse sequence for hyperpolarized (13)c mri
topic Imaging Methodology—Full Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297976/
https://www.ncbi.nlm.nih.gov/pubmed/26916384
http://dx.doi.org/10.1002/mrm.26168
work_keys_str_mv AT wangjiazheng singleshotthreedimensionalpulsesequenceforhyperpolarized13cmri
AT wrightalanj singleshotthreedimensionalpulsesequenceforhyperpolarized13cmri
AT hudeen singleshotthreedimensionalpulsesequenceforhyperpolarized13cmri
AT heskethrichard singleshotthreedimensionalpulsesequenceforhyperpolarized13cmri
AT brindlekevinm singleshotthreedimensionalpulsesequenceforhyperpolarized13cmri