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Single shot three‐dimensional pulse sequence for hyperpolarized (13)C MRI
PURPOSE: Metabolic imaging with hyperpolarized (13)C‐labeled cell substrates is a promising technique for imaging tissue metabolism in vivo. However, the transient nature of the hyperpolarization, and its depletion following excitation, limits the imaging time and the number of excitation pulses tha...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297976/ https://www.ncbi.nlm.nih.gov/pubmed/26916384 http://dx.doi.org/10.1002/mrm.26168 |
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author | Wang, Jiazheng Wright, Alan J. Hu, De‐en Hesketh, Richard Brindle, Kevin M. |
author_facet | Wang, Jiazheng Wright, Alan J. Hu, De‐en Hesketh, Richard Brindle, Kevin M. |
author_sort | Wang, Jiazheng |
collection | PubMed |
description | PURPOSE: Metabolic imaging with hyperpolarized (13)C‐labeled cell substrates is a promising technique for imaging tissue metabolism in vivo. However, the transient nature of the hyperpolarization, and its depletion following excitation, limits the imaging time and the number of excitation pulses that can be used. We describe here a single‐shot three‐dimensional (3D) imaging sequence and demonstrate its capability to generate (13)C MR images in tumor‐bearing mice injected with hyperpolarized [1‐(13)C]pyruvate. METHODS: The pulse sequence acquires a stack‐of‐spirals at two spin echoes after a single excitation pulse and encodes the kz‐dimension in an interleaved manner to enhance robustness to B(0) inhomogeneity. Spectral‐spatial pulses are used to acquire dynamic 3D images from selected hyperpolarized (13)C‐labeled metabolites. RESULTS: A nominal spatial/temporal resolution of 1.25 × 1.25 × 2.5 mm(3) × 2 s was achieved in tumor images of hyperpolarized [1‐(13)C]pyruvate and [1‐(13)C]lactate acquired in vivo. Higher resolution in the z‐direction, with a different k‐space trajectory, was demonstrated in measurements on a thermally polarized [1‐(13)C]lactate phantom. CONCLUSION: The pulse sequence is capable of imaging hyperpolarized (13)C‐labeled substrates at relatively high spatial and temporal resolutions and is robust to moderate system imperfections. Magn Reson Med 77:740–752, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
format | Online Article Text |
id | pubmed-5297976 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-52979762017-02-22 Single shot three‐dimensional pulse sequence for hyperpolarized (13)C MRI Wang, Jiazheng Wright, Alan J. Hu, De‐en Hesketh, Richard Brindle, Kevin M. Magn Reson Med Imaging Methodology—Full Papers PURPOSE: Metabolic imaging with hyperpolarized (13)C‐labeled cell substrates is a promising technique for imaging tissue metabolism in vivo. However, the transient nature of the hyperpolarization, and its depletion following excitation, limits the imaging time and the number of excitation pulses that can be used. We describe here a single‐shot three‐dimensional (3D) imaging sequence and demonstrate its capability to generate (13)C MR images in tumor‐bearing mice injected with hyperpolarized [1‐(13)C]pyruvate. METHODS: The pulse sequence acquires a stack‐of‐spirals at two spin echoes after a single excitation pulse and encodes the kz‐dimension in an interleaved manner to enhance robustness to B(0) inhomogeneity. Spectral‐spatial pulses are used to acquire dynamic 3D images from selected hyperpolarized (13)C‐labeled metabolites. RESULTS: A nominal spatial/temporal resolution of 1.25 × 1.25 × 2.5 mm(3) × 2 s was achieved in tumor images of hyperpolarized [1‐(13)C]pyruvate and [1‐(13)C]lactate acquired in vivo. Higher resolution in the z‐direction, with a different k‐space trajectory, was demonstrated in measurements on a thermally polarized [1‐(13)C]lactate phantom. CONCLUSION: The pulse sequence is capable of imaging hyperpolarized (13)C‐labeled substrates at relatively high spatial and temporal resolutions and is robust to moderate system imperfections. Magn Reson Med 77:740–752, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. John Wiley and Sons Inc. 2016-02-24 2017-02 /pmc/articles/PMC5297976/ /pubmed/26916384 http://dx.doi.org/10.1002/mrm.26168 Text en © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Imaging Methodology—Full Papers Wang, Jiazheng Wright, Alan J. Hu, De‐en Hesketh, Richard Brindle, Kevin M. Single shot three‐dimensional pulse sequence for hyperpolarized (13)C MRI |
title | Single shot three‐dimensional pulse sequence for hyperpolarized (13)C MRI |
title_full | Single shot three‐dimensional pulse sequence for hyperpolarized (13)C MRI |
title_fullStr | Single shot three‐dimensional pulse sequence for hyperpolarized (13)C MRI |
title_full_unstemmed | Single shot three‐dimensional pulse sequence for hyperpolarized (13)C MRI |
title_short | Single shot three‐dimensional pulse sequence for hyperpolarized (13)C MRI |
title_sort | single shot three‐dimensional pulse sequence for hyperpolarized (13)c mri |
topic | Imaging Methodology—Full Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5297976/ https://www.ncbi.nlm.nih.gov/pubmed/26916384 http://dx.doi.org/10.1002/mrm.26168 |
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