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Pharmacokinetic Evaluation of CYP3A4‐Mediated Drug‐Drug Interactions of Isavuconazole With Rifampin, Ketoconazole, Midazolam, and Ethinyl Estradiol/Norethindrone in Healthy Adults

This report describes the phase 1 trials that evaluated the metabolism of the novel triazole antifungal isavuconazole by cytochrome P450 3A4 (CYP3A4) and isavuconazole's effects on CYP3A4‐mediated metabolism in healthy adults. Coadministration of oral isavuconazole (100 mg once daily) with oral...

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Detalles Bibliográficos
Autores principales:	Townsend, Robert, Dietz, Albert, Hale, Christine, Akhtar, Shahzad, Kowalski, Donna, Lademacher, Christopher, Lasseter, Kenneth, Pearlman, Helene, Rammelsberg, Diane, Schmitt‐Hoffmann, Anne, Yamazaki, Takao, Desai, Amit
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298035/ https://www.ncbi.nlm.nih.gov/pubmed/27273461 http://dx.doi.org/10.1002/cpdd.285

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