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AMPA GluA1-flip targeted oligonucleotide therapy reduces neonatal seizures and hyperexcitability

Glutamate-activated α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPA-Rs) mediate the majority of excitatory neurotransmission in brain and thus are major drug targets for diseases associated with hyperexcitability or neurotoxicity. Due to the critical nature of AMPA-Rs in normal...

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Detalles Bibliográficos
Autores principales:	Lykens, Nicole M., Coughlin, David J., Reddi, Jyoti M., Lutz, Gordon J., Tallent, Melanie K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298276/ https://www.ncbi.nlm.nih.gov/pubmed/28178321 http://dx.doi.org/10.1371/journal.pone.0171538

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