Stem Cells for Diabetes Complications: A Future Potential Cure

Long-standing diabetes leads to structural and functional alterations in both the micro- and the macrovasculature. Designing therapies to repair these abnormalities present unique and sophisticated challenges. Vascular endothelial cells are the primary cells damaged by hyperglycemia-induced adverse...

Descripción completa

Detalles Bibliográficos
Autores principales: Khamaisi, Mogher, Balanson, Sarit Ella
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rambam Health Care Campus 2017
Materias:
Discoveries from Bench to the Bedside
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298369/
https://www.ncbi.nlm.nih.gov/pubmed/28178432
http://dx.doi.org/10.5041/RMMJ.10283
_version_ 1782505863203782656
author Khamaisi, Mogher
Balanson, Sarit Ella
author_facet Khamaisi, Mogher
Balanson, Sarit Ella
author_sort Khamaisi, Mogher
collection PubMed
description Long-standing diabetes leads to structural and functional alterations in both the micro- and the macrovasculature. Designing therapies to repair these abnormalities present unique and sophisticated challenges. Vascular endothelial cells are the primary cells damaged by hyperglycemia-induced adverse effects. Vascular stem cells that give rise to endothelial progenitor cells and mesenchymal progenitor cells represent an attractive target for cell therapy for diabetic patients. In this review, we shed light on challenges and recent advances surrounding stem cell therapies for diabetes vascular complications and discuss limitations for their clinical adoption.
format Online
Article
Text
id pubmed-5298369
institution National Center for Biotechnology Information
language English
publishDate 2017
publisher Rambam Health Care Campus
record_format MEDLINE/PubMed
spelling pubmed-52983692017-02-10 Stem Cells for Diabetes Complications: A Future Potential Cure Khamaisi, Mogher Balanson, Sarit Ella Rambam Maimonides Med J Discoveries from Bench to the Bedside Long-standing diabetes leads to structural and functional alterations in both the micro- and the macrovasculature. Designing therapies to repair these abnormalities present unique and sophisticated challenges. Vascular endothelial cells are the primary cells damaged by hyperglycemia-induced adverse effects. Vascular stem cells that give rise to endothelial progenitor cells and mesenchymal progenitor cells represent an attractive target for cell therapy for diabetic patients. In this review, we shed light on challenges and recent advances surrounding stem cell therapies for diabetes vascular complications and discuss limitations for their clinical adoption. Rambam Health Care Campus 2017-01-30 /pmc/articles/PMC5298369/ /pubmed/28178432 http://dx.doi.org/10.5041/RMMJ.10283 Text en © 2017 Khamaisi and Balanson This is an open-access article. All its content, except where otherwise noted, is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Discoveries from Bench to the Bedside
Khamaisi, Mogher
Balanson, Sarit Ella
Stem Cells for Diabetes Complications: A Future Potential Cure
title Stem Cells for Diabetes Complications: A Future Potential Cure
title_full Stem Cells for Diabetes Complications: A Future Potential Cure
title_fullStr Stem Cells for Diabetes Complications: A Future Potential Cure
title_full_unstemmed Stem Cells for Diabetes Complications: A Future Potential Cure
title_short Stem Cells for Diabetes Complications: A Future Potential Cure
title_sort stem cells for diabetes complications: a future potential cure
topic Discoveries from Bench to the Bedside
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298369/
https://www.ncbi.nlm.nih.gov/pubmed/28178432
http://dx.doi.org/10.5041/RMMJ.10283
work_keys_str_mv AT khamaisimogher stemcellsfordiabetescomplicationsafuturepotentialcure
AT balansonsaritella stemcellsfordiabetescomplicationsafuturepotentialcure

Ejemplares similares