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The additional utility of apparent diffusion coefficient values of clear-cell renal cell carcinoma for predicting metastasis during clinical staging

BACKGROUND: The apparent diffusion coefficient (ADC) value is known to be an indicator of tumor activity. The ADC value of high-grade clear-cell renal cell carcinoma (RCC) is significantly lower than that of low-grade clear-cell RCC. PURPOSE: To investigate the utility of ADC values of clear-cell RC...

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Autores principales: Yoshida, Rika, Yoshizako, Takeshi, Hisatoshi, Araki, Mori, Hiroshi, Tamaki, Yukihisa, Ishikawa, Noriyoshi, Kitagaki, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298554/
https://www.ncbi.nlm.nih.gov/pubmed/28210496
http://dx.doi.org/10.1177/2058460116687174
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author Yoshida, Rika
Yoshizako, Takeshi
Hisatoshi, Araki
Mori, Hiroshi
Tamaki, Yukihisa
Ishikawa, Noriyoshi
Kitagaki, Hajime
author_facet Yoshida, Rika
Yoshizako, Takeshi
Hisatoshi, Araki
Mori, Hiroshi
Tamaki, Yukihisa
Ishikawa, Noriyoshi
Kitagaki, Hajime
author_sort Yoshida, Rika
collection PubMed
description BACKGROUND: The apparent diffusion coefficient (ADC) value is known to be an indicator of tumor activity. The ADC value of high-grade clear-cell renal cell carcinoma (RCC) is significantly lower than that of low-grade clear-cell RCC. PURPOSE: To investigate the utility of ADC values of clear-cell RCC by comparing ADC values between groups with T1a RCC (tumor size ≤ 4 cm) without metastasis and the group with metastasis. MATERIAL AND METHODS: A retrospective review was performed on 51 patients with 51 RCCs who underwent 1.5 T magnetic resonance imaging (MRI) for evaluating a renal mass confirmed pathologically to be clear-cell RCC between January 2010 and August 2014. We compared ADC values between group A (T1a RCC without metastasis, T1aN0M0) and group B (RCC with metastasis) using the Mann–Whitney U test. RESULTS: The patients were divided into group A (n = 30; tumor size: median, 24.5 mm; range, 8–40 mm; ADC value [×10(−3) mm(2)/s]: median, 1.71; range, 1.23–2.24) and group B (n = 21; tumor size: median, 87.5 mm; range, 18–150 mm; ADC value [×10(−3) mm(2)/s]: median, 1.35; range, 0.91–1.94). The ADC value differed significantly between the two groups. The area under the receiver operating characteristic curve was 0.869. Using the optimum cutoff value (1.552 × 10(−3) mm(2)/s), ADC had a sensitivity of 80.0% and specificity of 81.0%. CONCLUSION: There was a statistically significant difference in the ADC between group A (T1a clear-cell RCC without distant metastasis) and group B (advanced clear-cell RCC with lymph node metastasis or distant metastasis).
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spelling pubmed-52985542017-02-16 The additional utility of apparent diffusion coefficient values of clear-cell renal cell carcinoma for predicting metastasis during clinical staging Yoshida, Rika Yoshizako, Takeshi Hisatoshi, Araki Mori, Hiroshi Tamaki, Yukihisa Ishikawa, Noriyoshi Kitagaki, Hajime Acta Radiol Open Research BACKGROUND: The apparent diffusion coefficient (ADC) value is known to be an indicator of tumor activity. The ADC value of high-grade clear-cell renal cell carcinoma (RCC) is significantly lower than that of low-grade clear-cell RCC. PURPOSE: To investigate the utility of ADC values of clear-cell RCC by comparing ADC values between groups with T1a RCC (tumor size ≤ 4 cm) without metastasis and the group with metastasis. MATERIAL AND METHODS: A retrospective review was performed on 51 patients with 51 RCCs who underwent 1.5 T magnetic resonance imaging (MRI) for evaluating a renal mass confirmed pathologically to be clear-cell RCC between January 2010 and August 2014. We compared ADC values between group A (T1a RCC without metastasis, T1aN0M0) and group B (RCC with metastasis) using the Mann–Whitney U test. RESULTS: The patients were divided into group A (n = 30; tumor size: median, 24.5 mm; range, 8–40 mm; ADC value [×10(−3) mm(2)/s]: median, 1.71; range, 1.23–2.24) and group B (n = 21; tumor size: median, 87.5 mm; range, 18–150 mm; ADC value [×10(−3) mm(2)/s]: median, 1.35; range, 0.91–1.94). The ADC value differed significantly between the two groups. The area under the receiver operating characteristic curve was 0.869. Using the optimum cutoff value (1.552 × 10(−3) mm(2)/s), ADC had a sensitivity of 80.0% and specificity of 81.0%. CONCLUSION: There was a statistically significant difference in the ADC between group A (T1a clear-cell RCC without distant metastasis) and group B (advanced clear-cell RCC with lymph node metastasis or distant metastasis). SAGE Publications 2017-01-01 /pmc/articles/PMC5298554/ /pubmed/28210496 http://dx.doi.org/10.1177/2058460116687174 Text en © The Foundation Acta Radiologica 2017 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Research
Yoshida, Rika
Yoshizako, Takeshi
Hisatoshi, Araki
Mori, Hiroshi
Tamaki, Yukihisa
Ishikawa, Noriyoshi
Kitagaki, Hajime
The additional utility of apparent diffusion coefficient values of clear-cell renal cell carcinoma for predicting metastasis during clinical staging
title The additional utility of apparent diffusion coefficient values of clear-cell renal cell carcinoma for predicting metastasis during clinical staging
title_full The additional utility of apparent diffusion coefficient values of clear-cell renal cell carcinoma for predicting metastasis during clinical staging
title_fullStr The additional utility of apparent diffusion coefficient values of clear-cell renal cell carcinoma for predicting metastasis during clinical staging
title_full_unstemmed The additional utility of apparent diffusion coefficient values of clear-cell renal cell carcinoma for predicting metastasis during clinical staging
title_short The additional utility of apparent diffusion coefficient values of clear-cell renal cell carcinoma for predicting metastasis during clinical staging
title_sort additional utility of apparent diffusion coefficient values of clear-cell renal cell carcinoma for predicting metastasis during clinical staging
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298554/
https://www.ncbi.nlm.nih.gov/pubmed/28210496
http://dx.doi.org/10.1177/2058460116687174
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