Cargando…
The additional utility of apparent diffusion coefficient values of clear-cell renal cell carcinoma for predicting metastasis during clinical staging
BACKGROUND: The apparent diffusion coefficient (ADC) value is known to be an indicator of tumor activity. The ADC value of high-grade clear-cell renal cell carcinoma (RCC) is significantly lower than that of low-grade clear-cell RCC. PURPOSE: To investigate the utility of ADC values of clear-cell RC...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
SAGE Publications
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298554/ https://www.ncbi.nlm.nih.gov/pubmed/28210496 http://dx.doi.org/10.1177/2058460116687174 |
_version_ | 1782505881868435456 |
---|---|
author | Yoshida, Rika Yoshizako, Takeshi Hisatoshi, Araki Mori, Hiroshi Tamaki, Yukihisa Ishikawa, Noriyoshi Kitagaki, Hajime |
author_facet | Yoshida, Rika Yoshizako, Takeshi Hisatoshi, Araki Mori, Hiroshi Tamaki, Yukihisa Ishikawa, Noriyoshi Kitagaki, Hajime |
author_sort | Yoshida, Rika |
collection | PubMed |
description | BACKGROUND: The apparent diffusion coefficient (ADC) value is known to be an indicator of tumor activity. The ADC value of high-grade clear-cell renal cell carcinoma (RCC) is significantly lower than that of low-grade clear-cell RCC. PURPOSE: To investigate the utility of ADC values of clear-cell RCC by comparing ADC values between groups with T1a RCC (tumor size ≤ 4 cm) without metastasis and the group with metastasis. MATERIAL AND METHODS: A retrospective review was performed on 51 patients with 51 RCCs who underwent 1.5 T magnetic resonance imaging (MRI) for evaluating a renal mass confirmed pathologically to be clear-cell RCC between January 2010 and August 2014. We compared ADC values between group A (T1a RCC without metastasis, T1aN0M0) and group B (RCC with metastasis) using the Mann–Whitney U test. RESULTS: The patients were divided into group A (n = 30; tumor size: median, 24.5 mm; range, 8–40 mm; ADC value [×10(−3) mm(2)/s]: median, 1.71; range, 1.23–2.24) and group B (n = 21; tumor size: median, 87.5 mm; range, 18–150 mm; ADC value [×10(−3) mm(2)/s]: median, 1.35; range, 0.91–1.94). The ADC value differed significantly between the two groups. The area under the receiver operating characteristic curve was 0.869. Using the optimum cutoff value (1.552 × 10(−3) mm(2)/s), ADC had a sensitivity of 80.0% and specificity of 81.0%. CONCLUSION: There was a statistically significant difference in the ADC between group A (T1a clear-cell RCC without distant metastasis) and group B (advanced clear-cell RCC with lymph node metastasis or distant metastasis). |
format | Online Article Text |
id | pubmed-5298554 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | SAGE Publications |
record_format | MEDLINE/PubMed |
spelling | pubmed-52985542017-02-16 The additional utility of apparent diffusion coefficient values of clear-cell renal cell carcinoma for predicting metastasis during clinical staging Yoshida, Rika Yoshizako, Takeshi Hisatoshi, Araki Mori, Hiroshi Tamaki, Yukihisa Ishikawa, Noriyoshi Kitagaki, Hajime Acta Radiol Open Research BACKGROUND: The apparent diffusion coefficient (ADC) value is known to be an indicator of tumor activity. The ADC value of high-grade clear-cell renal cell carcinoma (RCC) is significantly lower than that of low-grade clear-cell RCC. PURPOSE: To investigate the utility of ADC values of clear-cell RCC by comparing ADC values between groups with T1a RCC (tumor size ≤ 4 cm) without metastasis and the group with metastasis. MATERIAL AND METHODS: A retrospective review was performed on 51 patients with 51 RCCs who underwent 1.5 T magnetic resonance imaging (MRI) for evaluating a renal mass confirmed pathologically to be clear-cell RCC between January 2010 and August 2014. We compared ADC values between group A (T1a RCC without metastasis, T1aN0M0) and group B (RCC with metastasis) using the Mann–Whitney U test. RESULTS: The patients were divided into group A (n = 30; tumor size: median, 24.5 mm; range, 8–40 mm; ADC value [×10(−3) mm(2)/s]: median, 1.71; range, 1.23–2.24) and group B (n = 21; tumor size: median, 87.5 mm; range, 18–150 mm; ADC value [×10(−3) mm(2)/s]: median, 1.35; range, 0.91–1.94). The ADC value differed significantly between the two groups. The area under the receiver operating characteristic curve was 0.869. Using the optimum cutoff value (1.552 × 10(−3) mm(2)/s), ADC had a sensitivity of 80.0% and specificity of 81.0%. CONCLUSION: There was a statistically significant difference in the ADC between group A (T1a clear-cell RCC without distant metastasis) and group B (advanced clear-cell RCC with lymph node metastasis or distant metastasis). SAGE Publications 2017-01-01 /pmc/articles/PMC5298554/ /pubmed/28210496 http://dx.doi.org/10.1177/2058460116687174 Text en © The Foundation Acta Radiologica 2017 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page(https://us.sagepub.com/en-us/nam/open-access-at-sage). |
spellingShingle | Research Yoshida, Rika Yoshizako, Takeshi Hisatoshi, Araki Mori, Hiroshi Tamaki, Yukihisa Ishikawa, Noriyoshi Kitagaki, Hajime The additional utility of apparent diffusion coefficient values of clear-cell renal cell carcinoma for predicting metastasis during clinical staging |
title | The additional utility of apparent diffusion coefficient values of clear-cell renal cell carcinoma for predicting metastasis during clinical staging |
title_full | The additional utility of apparent diffusion coefficient values of clear-cell renal cell carcinoma for predicting metastasis during clinical staging |
title_fullStr | The additional utility of apparent diffusion coefficient values of clear-cell renal cell carcinoma for predicting metastasis during clinical staging |
title_full_unstemmed | The additional utility of apparent diffusion coefficient values of clear-cell renal cell carcinoma for predicting metastasis during clinical staging |
title_short | The additional utility of apparent diffusion coefficient values of clear-cell renal cell carcinoma for predicting metastasis during clinical staging |
title_sort | additional utility of apparent diffusion coefficient values of clear-cell renal cell carcinoma for predicting metastasis during clinical staging |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298554/ https://www.ncbi.nlm.nih.gov/pubmed/28210496 http://dx.doi.org/10.1177/2058460116687174 |
work_keys_str_mv | AT yoshidarika theadditionalutilityofapparentdiffusioncoefficientvaluesofclearcellrenalcellcarcinomaforpredictingmetastasisduringclinicalstaging AT yoshizakotakeshi theadditionalutilityofapparentdiffusioncoefficientvaluesofclearcellrenalcellcarcinomaforpredictingmetastasisduringclinicalstaging AT hisatoshiaraki theadditionalutilityofapparentdiffusioncoefficientvaluesofclearcellrenalcellcarcinomaforpredictingmetastasisduringclinicalstaging AT morihiroshi theadditionalutilityofapparentdiffusioncoefficientvaluesofclearcellrenalcellcarcinomaforpredictingmetastasisduringclinicalstaging AT tamakiyukihisa theadditionalutilityofapparentdiffusioncoefficientvaluesofclearcellrenalcellcarcinomaforpredictingmetastasisduringclinicalstaging AT ishikawanoriyoshi theadditionalutilityofapparentdiffusioncoefficientvaluesofclearcellrenalcellcarcinomaforpredictingmetastasisduringclinicalstaging AT kitagakihajime theadditionalutilityofapparentdiffusioncoefficientvaluesofclearcellrenalcellcarcinomaforpredictingmetastasisduringclinicalstaging AT yoshidarika additionalutilityofapparentdiffusioncoefficientvaluesofclearcellrenalcellcarcinomaforpredictingmetastasisduringclinicalstaging AT yoshizakotakeshi additionalutilityofapparentdiffusioncoefficientvaluesofclearcellrenalcellcarcinomaforpredictingmetastasisduringclinicalstaging AT hisatoshiaraki additionalutilityofapparentdiffusioncoefficientvaluesofclearcellrenalcellcarcinomaforpredictingmetastasisduringclinicalstaging AT morihiroshi additionalutilityofapparentdiffusioncoefficientvaluesofclearcellrenalcellcarcinomaforpredictingmetastasisduringclinicalstaging AT tamakiyukihisa additionalutilityofapparentdiffusioncoefficientvaluesofclearcellrenalcellcarcinomaforpredictingmetastasisduringclinicalstaging AT ishikawanoriyoshi additionalutilityofapparentdiffusioncoefficientvaluesofclearcellrenalcellcarcinomaforpredictingmetastasisduringclinicalstaging AT kitagakihajime additionalutilityofapparentdiffusioncoefficientvaluesofclearcellrenalcellcarcinomaforpredictingmetastasisduringclinicalstaging |