Significance of Cancer Stem Cells in Anti-Cancer Therapies

Stem cells are the focus of cutting edge research interest because of their competence both to self-renew and proliferate, and to differentiate into a variety of tissues, offering enticing prospects of growing replacement organs in vitro, among other possible therapeutic implications. It is conceiva...

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Detalles Bibliográficos
Autores principales: Botelho, Mónica, Alves, Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298826/
https://www.ncbi.nlm.nih.gov/pubmed/28191547
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author Botelho, Mónica
Alves, Helena
author_facet Botelho, Mónica
Alves, Helena
author_sort Botelho, Mónica
collection PubMed
description Stem cells are the focus of cutting edge research interest because of their competence both to self-renew and proliferate, and to differentiate into a variety of tissues, offering enticing prospects of growing replacement organs in vitro, among other possible therapeutic implications. It is conceivable that cancer stem cells share a number of biological hallmarks that are different from their normal-tissue counterparts and that these might be taken advantage of for therapeutic benefits. In this review we discuss the significance of cancer stem cells in diagnosis and prognosis of cancer as well as in the development of new strategies for anti-cancer drug design.
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spelling pubmed-52988262017-02-08 Significance of Cancer Stem Cells in Anti-Cancer Therapies Botelho, Mónica Alves, Helena Int J Immunother Cancer Res Article Stem cells are the focus of cutting edge research interest because of their competence both to self-renew and proliferate, and to differentiate into a variety of tissues, offering enticing prospects of growing replacement organs in vitro, among other possible therapeutic implications. It is conceivable that cancer stem cells share a number of biological hallmarks that are different from their normal-tissue counterparts and that these might be taken advantage of for therapeutic benefits. In this review we discuss the significance of cancer stem cells in diagnosis and prognosis of cancer as well as in the development of new strategies for anti-cancer drug design. 2016-12-31 2016 /pmc/articles/PMC5298826/ /pubmed/28191547 Text en http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Article
Botelho, Mónica
Alves, Helena
Significance of Cancer Stem Cells in Anti-Cancer Therapies
title Significance of Cancer Stem Cells in Anti-Cancer Therapies
title_full Significance of Cancer Stem Cells in Anti-Cancer Therapies
title_fullStr Significance of Cancer Stem Cells in Anti-Cancer Therapies
title_full_unstemmed Significance of Cancer Stem Cells in Anti-Cancer Therapies
title_short Significance of Cancer Stem Cells in Anti-Cancer Therapies
title_sort significance of cancer stem cells in anti-cancer therapies
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5298826/
https://www.ncbi.nlm.nih.gov/pubmed/28191547
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