Functional and Antigen-Specific Serum Antibody Levels as Correlates of Protection against Shigellosis in a Controlled Human Challenge Study

Shigella is an important cause of diarrheal disease in young children living in developing countries. No approved vaccines are available, and the development of vaccine candidates has been hindered by the lack of firm immunological correlates of protection, among other reasons. To address this gap i...

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Autores principales: Shimanovich, Avital A., Buskirk, Amanda D., Heine, Shannon J., Blackwelder, William C., Wahid, Rezwanul, Kotloff, Karen L., Pasetti, Marcela F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Clinical Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299116/
https://www.ncbi.nlm.nih.gov/pubmed/27927680
http://dx.doi.org/10.1128/CVI.00412-16

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