Atoh1 as a Coordinator of Sensory Hair Cell Development and Regeneration in the Cochlea

Cochlear sensory hair cells (HCs) are crucial for hearing as mechanoreceptors of the auditory systems. Clarification of transcriptional regulation for the cochlear sensory HC development is crucial for the improvement of cell replacement therapies for hearing loss. Transcription factor Atoh1 is the...

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Detalles Bibliográficos
Autores principales: Lee, Sungsu, Jeong, Han-Seong, Cho, Hyong-Ho
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Chonnam National University Medical School 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299128/
https://www.ncbi.nlm.nih.gov/pubmed/28184337
http://dx.doi.org/10.4068/cmj.2017.53.1.37
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author Lee, Sungsu
Jeong, Han-Seong
Cho, Hyong-Ho
author_facet Lee, Sungsu
Jeong, Han-Seong
Cho, Hyong-Ho
author_sort Lee, Sungsu
collection PubMed
description Cochlear sensory hair cells (HCs) are crucial for hearing as mechanoreceptors of the auditory systems. Clarification of transcriptional regulation for the cochlear sensory HC development is crucial for the improvement of cell replacement therapies for hearing loss. Transcription factor Atoh1 is the key player during HC development and regeneration. In this review, we will focus on Atoh1 and its related signaling pathways (Notch, fibroblast growth factor, and Wnt/β-catenin signaling) involved in the development of cochlear sensory HCs. We will also discuss the potential applicability of these signals for the induction of HC regeneration.
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spelling pubmed-52991282017-02-09 Atoh1 as a Coordinator of Sensory Hair Cell Development and Regeneration in the Cochlea Lee, Sungsu Jeong, Han-Seong Cho, Hyong-Ho Chonnam Med J Review Article Cochlear sensory hair cells (HCs) are crucial for hearing as mechanoreceptors of the auditory systems. Clarification of transcriptional regulation for the cochlear sensory HC development is crucial for the improvement of cell replacement therapies for hearing loss. Transcription factor Atoh1 is the key player during HC development and regeneration. In this review, we will focus on Atoh1 and its related signaling pathways (Notch, fibroblast growth factor, and Wnt/β-catenin signaling) involved in the development of cochlear sensory HCs. We will also discuss the potential applicability of these signals for the induction of HC regeneration. Chonnam National University Medical School 2017-01 2017-01-25 /pmc/articles/PMC5299128/ /pubmed/28184337 http://dx.doi.org/10.4068/cmj.2017.53.1.37 Text en © Chonnam Medical Journal, 2017 http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Lee, Sungsu
Jeong, Han-Seong
Cho, Hyong-Ho
Atoh1 as a Coordinator of Sensory Hair Cell Development and Regeneration in the Cochlea
title Atoh1 as a Coordinator of Sensory Hair Cell Development and Regeneration in the Cochlea
title_full Atoh1 as a Coordinator of Sensory Hair Cell Development and Regeneration in the Cochlea
title_fullStr Atoh1 as a Coordinator of Sensory Hair Cell Development and Regeneration in the Cochlea
title_full_unstemmed Atoh1 as a Coordinator of Sensory Hair Cell Development and Regeneration in the Cochlea
title_short Atoh1 as a Coordinator of Sensory Hair Cell Development and Regeneration in the Cochlea
title_sort atoh1 as a coordinator of sensory hair cell development and regeneration in the cochlea
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299128/
https://www.ncbi.nlm.nih.gov/pubmed/28184337
http://dx.doi.org/10.4068/cmj.2017.53.1.37
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AT chohyongho atoh1asacoordinatorofsensoryhaircelldevelopmentandregenerationinthecochlea

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