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Influence of IL-18 and IL-10 Polymorphisms on Tacrolimus Elimination in Chinese Lung Transplant Patients

Aims. The influence of interleukin-10 (IL-10) and interleukin-18 (IL-18) polymorphisms on tacrolimus pharmacokinetics had been described in liver and kidney transplantation. The expression of cytokines varied in different kinds of transplantation. The influence of IL-10 and IL-18 genetic polymorphis...

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Autores principales: Zhang, Xiaoqing, Xu, Jiandong, Fan, Junwei, Zhang, Tao, Li, Yuping, Xie, Boxiong, Zhang, Wei, Lin, Shengtao, Ye, Ling, Liu, Yuan, Jiang, Gening
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299197/
https://www.ncbi.nlm.nih.gov/pubmed/28246425
http://dx.doi.org/10.1155/2017/7834035
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author Zhang, Xiaoqing
Xu, Jiandong
Fan, Junwei
Zhang, Tao
Li, Yuping
Xie, Boxiong
Zhang, Wei
Lin, Shengtao
Ye, Ling
Liu, Yuan
Jiang, Gening
author_facet Zhang, Xiaoqing
Xu, Jiandong
Fan, Junwei
Zhang, Tao
Li, Yuping
Xie, Boxiong
Zhang, Wei
Lin, Shengtao
Ye, Ling
Liu, Yuan
Jiang, Gening
author_sort Zhang, Xiaoqing
collection PubMed
description Aims. The influence of interleukin-10 (IL-10) and interleukin-18 (IL-18) polymorphisms on tacrolimus pharmacokinetics had been described in liver and kidney transplantation. The expression of cytokines varied in different kinds of transplantation. The influence of IL-10 and IL-18 genetic polymorphisms on the pharmacokinetic parameters of tacrolimus remains unclear in lung transplantation. Methods. 51 lung transplant patients at Shanghai Pulmonary Hospital were included. IL-18 polymorphisms (rs5744247 and rs1946518), IL-10 polymorphisms (rs1800896, rs1800872, and rs3021097), and CYP3A5 rs776746 were genotyped. Dose-adjusted trough blood concentrations (C/D ratio, mg/kg body weight) in lung transplant patients during the first 4 postoperative weeks were calculated. Results. IL-18 rs5744247 allele C and rs1946518 allele A were associated with fast tacrolimus metabolism. Combined analysis showed that the numbers of low IL-18 mRNA expression alleles had positive correlation with tacrolimus C/D ratios in lung transplant recipients. The influence of IL-18 polymorphisms on tacrolimus C/D ratios was observed in CYP3A5 expresser recipients, but not in CYP3A5 nonexpresser recipients. No clinical significance of tacrolimus C/D ratios difference of IL-10 polymorphisms was found in our data. Conclusions. IL-18 polymorphisms may influence tacrolimus elimination in lung transplantation patients.
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spelling pubmed-52991972017-02-28 Influence of IL-18 and IL-10 Polymorphisms on Tacrolimus Elimination in Chinese Lung Transplant Patients Zhang, Xiaoqing Xu, Jiandong Fan, Junwei Zhang, Tao Li, Yuping Xie, Boxiong Zhang, Wei Lin, Shengtao Ye, Ling Liu, Yuan Jiang, Gening Dis Markers Research Article Aims. The influence of interleukin-10 (IL-10) and interleukin-18 (IL-18) polymorphisms on tacrolimus pharmacokinetics had been described in liver and kidney transplantation. The expression of cytokines varied in different kinds of transplantation. The influence of IL-10 and IL-18 genetic polymorphisms on the pharmacokinetic parameters of tacrolimus remains unclear in lung transplantation. Methods. 51 lung transplant patients at Shanghai Pulmonary Hospital were included. IL-18 polymorphisms (rs5744247 and rs1946518), IL-10 polymorphisms (rs1800896, rs1800872, and rs3021097), and CYP3A5 rs776746 were genotyped. Dose-adjusted trough blood concentrations (C/D ratio, mg/kg body weight) in lung transplant patients during the first 4 postoperative weeks were calculated. Results. IL-18 rs5744247 allele C and rs1946518 allele A were associated with fast tacrolimus metabolism. Combined analysis showed that the numbers of low IL-18 mRNA expression alleles had positive correlation with tacrolimus C/D ratios in lung transplant recipients. The influence of IL-18 polymorphisms on tacrolimus C/D ratios was observed in CYP3A5 expresser recipients, but not in CYP3A5 nonexpresser recipients. No clinical significance of tacrolimus C/D ratios difference of IL-10 polymorphisms was found in our data. Conclusions. IL-18 polymorphisms may influence tacrolimus elimination in lung transplantation patients. Hindawi Publishing Corporation 2017 2017-01-26 /pmc/articles/PMC5299197/ /pubmed/28246425 http://dx.doi.org/10.1155/2017/7834035 Text en Copyright © 2017 Xiaoqing Zhang et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhang, Xiaoqing
Xu, Jiandong
Fan, Junwei
Zhang, Tao
Li, Yuping
Xie, Boxiong
Zhang, Wei
Lin, Shengtao
Ye, Ling
Liu, Yuan
Jiang, Gening
Influence of IL-18 and IL-10 Polymorphisms on Tacrolimus Elimination in Chinese Lung Transplant Patients
title Influence of IL-18 and IL-10 Polymorphisms on Tacrolimus Elimination in Chinese Lung Transplant Patients
title_full Influence of IL-18 and IL-10 Polymorphisms on Tacrolimus Elimination in Chinese Lung Transplant Patients
title_fullStr Influence of IL-18 and IL-10 Polymorphisms on Tacrolimus Elimination in Chinese Lung Transplant Patients
title_full_unstemmed Influence of IL-18 and IL-10 Polymorphisms on Tacrolimus Elimination in Chinese Lung Transplant Patients
title_short Influence of IL-18 and IL-10 Polymorphisms on Tacrolimus Elimination in Chinese Lung Transplant Patients
title_sort influence of il-18 and il-10 polymorphisms on tacrolimus elimination in chinese lung transplant patients
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299197/
https://www.ncbi.nlm.nih.gov/pubmed/28246425
http://dx.doi.org/10.1155/2017/7834035
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