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The NRF2 transcriptional target, OSGIN1, contributes to monomethyl fumarate-mediated cytoprotection in human astrocytes

Dimethyl fumarate (DMF) is indicated for the treatment of relapsing multiple sclerosis and may exert therapeutic effects via activation of the nuclear factor (erythroid-derived 2)-like 2 (NRF2) pathway. Following oral DMF administration, central nervous system (CNS) tissue is predominantly exposed t...

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Detalles Bibliográficos
Autores principales:	Brennan, Melanie S., Matos, Maria F., Richter, Karl E., Li, Bing, Scannevin, Robert H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299414/ https://www.ncbi.nlm.nih.gov/pubmed/28181536 http://dx.doi.org/10.1038/srep42054

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