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Platelet responses to agonists in a cohort of highly characterised platelet donors are consistent over time
BACKGROUND AND OBJECTIVES: Platelet function shows significant inheritance that is at least partially genetically controlled. There is also evidence that the platelet response is stable over time, but there are few studies that have assessed consistency of platelet function over months and years. We...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299478/ https://www.ncbi.nlm.nih.gov/pubmed/28001309 http://dx.doi.org/10.1111/vox.12468 |
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author | Garner, S. F. Furnell, A. Kahan, B. C. Jones, C. I. Attwood, A. Harrison, P. Kelly, A. M. Goodall, A. H. Cardigan, R. Ouwehand, W. H. |
author_facet | Garner, S. F. Furnell, A. Kahan, B. C. Jones, C. I. Attwood, A. Harrison, P. Kelly, A. M. Goodall, A. H. Cardigan, R. Ouwehand, W. H. |
author_sort | Garner, S. F. |
collection | PubMed |
description | BACKGROUND AND OBJECTIVES: Platelet function shows significant inheritance that is at least partially genetically controlled. There is also evidence that the platelet response is stable over time, but there are few studies that have assessed consistency of platelet function over months and years. We aimed to measure platelet function in platelet donors over time in individuals selected from a cohort of 956 donors whose platelet function had been previously characterised. MATERIALS AND METHODS: Platelet function was assessed by flow cytometry, measuring fibrinogen binding and P‐selectin expression after stimulation with either cross‐linked collagen‐related peptide or adenosine 5′‐diphosphate. Eighty‐nine donors from the Cambridge Platelet Function Cohort whose platelet responses were initially within the lower or upper decile of reactivity were retested between 4 months and five and a half years later. RESULTS: There was moderate‐to‐high correlation between the initial and repeat platelet function results for all assays (P ≤ 0·007, r (2) 0·2961–0·7625); furthermore, the range of results observed in the initial low and high responder groups remained significantly different at the time of the second test (P ≤ 0·0005). CONCLUSION: Platelet function remains consistent over time. This implies that this potential influence on quality of donated platelet concentrates will remain essentially constant for a given donor. |
format | Online Article Text |
id | pubmed-5299478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-52994782017-02-22 Platelet responses to agonists in a cohort of highly characterised platelet donors are consistent over time Garner, S. F. Furnell, A. Kahan, B. C. Jones, C. I. Attwood, A. Harrison, P. Kelly, A. M. Goodall, A. H. Cardigan, R. Ouwehand, W. H. Vox Sang Blood Component Collection and Production BACKGROUND AND OBJECTIVES: Platelet function shows significant inheritance that is at least partially genetically controlled. There is also evidence that the platelet response is stable over time, but there are few studies that have assessed consistency of platelet function over months and years. We aimed to measure platelet function in platelet donors over time in individuals selected from a cohort of 956 donors whose platelet function had been previously characterised. MATERIALS AND METHODS: Platelet function was assessed by flow cytometry, measuring fibrinogen binding and P‐selectin expression after stimulation with either cross‐linked collagen‐related peptide or adenosine 5′‐diphosphate. Eighty‐nine donors from the Cambridge Platelet Function Cohort whose platelet responses were initially within the lower or upper decile of reactivity were retested between 4 months and five and a half years later. RESULTS: There was moderate‐to‐high correlation between the initial and repeat platelet function results for all assays (P ≤ 0·007, r (2) 0·2961–0·7625); furthermore, the range of results observed in the initial low and high responder groups remained significantly different at the time of the second test (P ≤ 0·0005). CONCLUSION: Platelet function remains consistent over time. This implies that this potential influence on quality of donated platelet concentrates will remain essentially constant for a given donor. John Wiley and Sons Inc. 2016-12-21 2017-01 /pmc/articles/PMC5299478/ /pubmed/28001309 http://dx.doi.org/10.1111/vox.12468 Text en © 2016 The Authors. Vox Sanguinis published by John Wiley & Sons Ltd on behalf of International Society of Blood Transfusion. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Blood Component Collection and Production Garner, S. F. Furnell, A. Kahan, B. C. Jones, C. I. Attwood, A. Harrison, P. Kelly, A. M. Goodall, A. H. Cardigan, R. Ouwehand, W. H. Platelet responses to agonists in a cohort of highly characterised platelet donors are consistent over time |
title | Platelet responses to agonists in a cohort of highly characterised platelet donors are consistent over time |
title_full | Platelet responses to agonists in a cohort of highly characterised platelet donors are consistent over time |
title_fullStr | Platelet responses to agonists in a cohort of highly characterised platelet donors are consistent over time |
title_full_unstemmed | Platelet responses to agonists in a cohort of highly characterised platelet donors are consistent over time |
title_short | Platelet responses to agonists in a cohort of highly characterised platelet donors are consistent over time |
title_sort | platelet responses to agonists in a cohort of highly characterised platelet donors are consistent over time |
topic | Blood Component Collection and Production |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299478/ https://www.ncbi.nlm.nih.gov/pubmed/28001309 http://dx.doi.org/10.1111/vox.12468 |
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