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Surface Accessibility and Dynamics of Macromolecular Assemblies Probed by Covalent Labeling Mass Spectrometry and Integrative Modeling

[Image: see text] Mass spectrometry (MS) has become an indispensable tool for investigating the architectures and dynamics of macromolecular assemblies. Here we show that covalent labeling of solvent accessible residues followed by their MS-based identification yields modeling restraints that allow...

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Detalles Bibliográficos
Autores principales:	Schmidt, Carla, Macpherson, Jamie A., Lau, Andy M., Tan, Ken Wei, Fraternali, Franca, Politis, Argyris
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2017
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299547/ https://www.ncbi.nlm.nih.gov/pubmed/28208298 http://dx.doi.org/10.1021/acs.analchem.6b02875

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