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Extensive Ca(2+) leak through K4750Q cardiac ryanodine receptors caused by cytosolic and luminal Ca(2+) hypersensitivity

Various ryanodine receptor 2 (RyR2) point mutations cause catecholamine-induced polymorphic ventricular tachycardia (CPVT), a life-threatening arrhythmia evoked by diastolic intracellular Ca(2+) release dysfunction. These mutations occur in essential regions of RyR2 that regulate Ca(2+) release. The...

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Detalles Bibliográficos
Autores principales:	Uehara, Akira, Murayama, Takashi, Yasukochi, Midori, Fill, Michael, Horie, Minoru, Okamoto, Toru, Matsuura, Yoshiharu, Uehara, Kiyoko, Fujimoto, Takahiro, Sakurai, Takashi, Kurebayashi, Nagomi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2017
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299618/ https://www.ncbi.nlm.nih.gov/pubmed/28082361 http://dx.doi.org/10.1085/jgp.201611624

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