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Imatinib relaxes the pulmonary venous bed of guinea pigs

BACKGROUND: Recently, the IMPRES study revealed that systemic imatinib improves exercise capacity in patients with advanced pulmonary arterial hypertension. Imatinib blocks the tyrosine kinase activity of the platelet-derived growth factor (PDGF)-receptor (PDGFR), acts antiproliferative and relaxes...

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Detalles Bibliográficos
Autores principales:	Maihöfer, Nina A., Suleiman, Said, Dreymüller, Daniela, Manley, Paul W., Rossaint, Rolf, Uhlig, Stefan, Martin, Christian, Rieg, Annette D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2017
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299687/ https://www.ncbi.nlm.nih.gov/pubmed/28178968 http://dx.doi.org/10.1186/s12931-017-0514-0

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