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Proportion and clinical features of never-smokers with non-small cell lung cancer

BACKGROUND: The proportion of never-smokers with non-small cell lung cancer (NSCLC) is increasing, but that in Korea has not been well addressed in a large population. We aimed to evaluate the proportion and clinical features of never-smokers with NSCLC in a large single institution. METHODS: We ana...

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Autores principales: Cho, Jaeyoung, Choi, Sun Mi, Lee, Jinwoo, Lee, Chang-Hoon, Lee, Sang-Min, Kim, Dong-Wan, Yim, Jae-Joon, Kim, Young Tae, Yoo, Chul-Gyu, Kim, Young Whan, Han, Sung Koo, Park, Young Sik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299770/
https://www.ncbi.nlm.nih.gov/pubmed/28179026
http://dx.doi.org/10.1186/s40880-017-0187-6
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author Cho, Jaeyoung
Choi, Sun Mi
Lee, Jinwoo
Lee, Chang-Hoon
Lee, Sang-Min
Kim, Dong-Wan
Yim, Jae-Joon
Kim, Young Tae
Yoo, Chul-Gyu
Kim, Young Whan
Han, Sung Koo
Park, Young Sik
author_facet Cho, Jaeyoung
Choi, Sun Mi
Lee, Jinwoo
Lee, Chang-Hoon
Lee, Sang-Min
Kim, Dong-Wan
Yim, Jae-Joon
Kim, Young Tae
Yoo, Chul-Gyu
Kim, Young Whan
Han, Sung Koo
Park, Young Sik
author_sort Cho, Jaeyoung
collection PubMed
description BACKGROUND: The proportion of never-smokers with non-small cell lung cancer (NSCLC) is increasing, but that in Korea has not been well addressed in a large population. We aimed to evaluate the proportion and clinical features of never-smokers with NSCLC in a large single institution. METHODS: We analyzed clinical data of 1860 consecutive patients who were newly diagnosed with NSCLC between June 2011 and December 2014. RESULTS: Of the 1860 NSCLC patients, 707 (38.0%) were never-smokers. The proportions of women (83.7% vs. 5.6%) and adenocarcinoma (89.8% vs. 44.9%) were higher among never-smokers than among ever-smokers. Significantly more never-smokers were diagnosed at a younger median age (65 vs. 68 years, P < 0.001) and earlier stage (stage I–II, 44.5% vs. 38.9%, P = 0.015) compared with ever-smokers. Epidermal growth factor receptor mutations (57.8% vs. 24.4%, P < 0.001) and anaplastic lymphoma kinase rearrangements (7.8% vs. 2.8%, P < 0.001) were more common in never-smokers, whereas Kirsten rat sarcoma viral oncogene homolog mutations (5.8% vs. 9.6%, P = 0.021) were less frequently encountered in never-smokers than in ever-smokers. Never-smokers showed longer survival after adjusting for the favorable effects of younger age, female sex, adenocarcinoma histology, better performance status, early stage disease, being asymptomatic at diagnosis, received antitumor treatment, and the presence of driver mutations (hazard ratio, 0.624; 95% confidence interval, 0.460–0.848; P = 0.003). CONCLUSIONS: More than one-third of the Korean patients with NSCLC were never-smokers. NSCLC in never-smokers had different clinical characteristics and major driver mutations and resulted in longer overall survival compared with NSCLC in ever-smokers.
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spelling pubmed-52997702017-02-13 Proportion and clinical features of never-smokers with non-small cell lung cancer Cho, Jaeyoung Choi, Sun Mi Lee, Jinwoo Lee, Chang-Hoon Lee, Sang-Min Kim, Dong-Wan Yim, Jae-Joon Kim, Young Tae Yoo, Chul-Gyu Kim, Young Whan Han, Sung Koo Park, Young Sik Chin J Cancer Original Article BACKGROUND: The proportion of never-smokers with non-small cell lung cancer (NSCLC) is increasing, but that in Korea has not been well addressed in a large population. We aimed to evaluate the proportion and clinical features of never-smokers with NSCLC in a large single institution. METHODS: We analyzed clinical data of 1860 consecutive patients who were newly diagnosed with NSCLC between June 2011 and December 2014. RESULTS: Of the 1860 NSCLC patients, 707 (38.0%) were never-smokers. The proportions of women (83.7% vs. 5.6%) and adenocarcinoma (89.8% vs. 44.9%) were higher among never-smokers than among ever-smokers. Significantly more never-smokers were diagnosed at a younger median age (65 vs. 68 years, P < 0.001) and earlier stage (stage I–II, 44.5% vs. 38.9%, P = 0.015) compared with ever-smokers. Epidermal growth factor receptor mutations (57.8% vs. 24.4%, P < 0.001) and anaplastic lymphoma kinase rearrangements (7.8% vs. 2.8%, P < 0.001) were more common in never-smokers, whereas Kirsten rat sarcoma viral oncogene homolog mutations (5.8% vs. 9.6%, P = 0.021) were less frequently encountered in never-smokers than in ever-smokers. Never-smokers showed longer survival after adjusting for the favorable effects of younger age, female sex, adenocarcinoma histology, better performance status, early stage disease, being asymptomatic at diagnosis, received antitumor treatment, and the presence of driver mutations (hazard ratio, 0.624; 95% confidence interval, 0.460–0.848; P = 0.003). CONCLUSIONS: More than one-third of the Korean patients with NSCLC were never-smokers. NSCLC in never-smokers had different clinical characteristics and major driver mutations and resulted in longer overall survival compared with NSCLC in ever-smokers. BioMed Central 2017-02-08 /pmc/articles/PMC5299770/ /pubmed/28179026 http://dx.doi.org/10.1186/s40880-017-0187-6 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Original Article
Cho, Jaeyoung
Choi, Sun Mi
Lee, Jinwoo
Lee, Chang-Hoon
Lee, Sang-Min
Kim, Dong-Wan
Yim, Jae-Joon
Kim, Young Tae
Yoo, Chul-Gyu
Kim, Young Whan
Han, Sung Koo
Park, Young Sik
Proportion and clinical features of never-smokers with non-small cell lung cancer
title Proportion and clinical features of never-smokers with non-small cell lung cancer
title_full Proportion and clinical features of never-smokers with non-small cell lung cancer
title_fullStr Proportion and clinical features of never-smokers with non-small cell lung cancer
title_full_unstemmed Proportion and clinical features of never-smokers with non-small cell lung cancer
title_short Proportion and clinical features of never-smokers with non-small cell lung cancer
title_sort proportion and clinical features of never-smokers with non-small cell lung cancer
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5299770/
https://www.ncbi.nlm.nih.gov/pubmed/28179026
http://dx.doi.org/10.1186/s40880-017-0187-6
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