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Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study

Noise-induced hearing loss (NIHL) is the second-most frequent form of sensorineural hearing loss. When exposed to the same noise, some workers develop NIHL while others do not, suggesting that NIHL may be associated with genetic factors. To explore the relationship between single nucleotide polymorp...

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Autores principales: Li, Yanhong, Yu, Shanfa, Gu, Guizhen, Chen, Guoshun, Zheng, Yuxin, Jiao, Jie, Zhou, Wenhui, Wu, Hui, Zhang, Zengrui, Zhang, Huanling, He, Lihua, Yang, Qiuyue, Xu, Xiangrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300111/
https://www.ncbi.nlm.nih.gov/pubmed/28182740
http://dx.doi.org/10.1371/journal.pone.0171722
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author Li, Yanhong
Yu, Shanfa
Gu, Guizhen
Chen, Guoshun
Zheng, Yuxin
Jiao, Jie
Zhou, Wenhui
Wu, Hui
Zhang, Zengrui
Zhang, Huanling
He, Lihua
Yang, Qiuyue
Xu, Xiangrong
author_facet Li, Yanhong
Yu, Shanfa
Gu, Guizhen
Chen, Guoshun
Zheng, Yuxin
Jiao, Jie
Zhou, Wenhui
Wu, Hui
Zhang, Zengrui
Zhang, Huanling
He, Lihua
Yang, Qiuyue
Xu, Xiangrong
author_sort Li, Yanhong
collection PubMed
description Noise-induced hearing loss (NIHL) is the second-most frequent form of sensorineural hearing loss. When exposed to the same noise, some workers develop NIHL while others do not, suggesting that NIHL may be associated with genetic factors. To explore the relationship between single nucleotide polymorphisms (SNPs) in heat shock protein 70 (HSP70) genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility to NIHL in Han Chinese workers exposed to noise, a case-control association study was carried out with 286 hearing loss cases and 286 matched with gender, age, type of work, and exposure time, drawn from a population of 3790 noise-exposed workers. Four SNPs were selected and genotyped. Subsequently, the effects of the alleles and genotypes of the three HSP70 genes (HSPA1A, HSPA1B and HSPA1L) on NIHL were analyzed by using a conditional logistic regression. A generalized multiple dimensionality reduction (GMDR) was applied to further detect an interaction between the four SNPs. Compared with the combined genotypes CC/TC, carriers of the TT genotype of rs2763979 appeared to show greater susceptibility to NIHL (P = 0.042, adjusted OR = 1.731, 95% CI 1.021–2.935). A significant interaction between rs2763979 and CNE was found (P = 0.029), and a significant association was found between TT of s2763979 and NIHL (P = 0.024, adjusted OR = 5.694, 95%CI 1.256-25.817) in the 96 dB (A)≤CNE<101 dB (A) group. The results suggest that the rs2763979 locus of the HSP70 genes may be associated with susceptibility to NIHL in Chinese individuals, and other HSP70 genes may also be susceptibility genes for NIHL, but the results must be further replicated in additional independent sample sets.
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spelling pubmed-53001112017-02-28 Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study Li, Yanhong Yu, Shanfa Gu, Guizhen Chen, Guoshun Zheng, Yuxin Jiao, Jie Zhou, Wenhui Wu, Hui Zhang, Zengrui Zhang, Huanling He, Lihua Yang, Qiuyue Xu, Xiangrong PLoS One Research Article Noise-induced hearing loss (NIHL) is the second-most frequent form of sensorineural hearing loss. When exposed to the same noise, some workers develop NIHL while others do not, suggesting that NIHL may be associated with genetic factors. To explore the relationship between single nucleotide polymorphisms (SNPs) in heat shock protein 70 (HSP70) genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility to NIHL in Han Chinese workers exposed to noise, a case-control association study was carried out with 286 hearing loss cases and 286 matched with gender, age, type of work, and exposure time, drawn from a population of 3790 noise-exposed workers. Four SNPs were selected and genotyped. Subsequently, the effects of the alleles and genotypes of the three HSP70 genes (HSPA1A, HSPA1B and HSPA1L) on NIHL were analyzed by using a conditional logistic regression. A generalized multiple dimensionality reduction (GMDR) was applied to further detect an interaction between the four SNPs. Compared with the combined genotypes CC/TC, carriers of the TT genotype of rs2763979 appeared to show greater susceptibility to NIHL (P = 0.042, adjusted OR = 1.731, 95% CI 1.021–2.935). A significant interaction between rs2763979 and CNE was found (P = 0.029), and a significant association was found between TT of s2763979 and NIHL (P = 0.024, adjusted OR = 5.694, 95%CI 1.256-25.817) in the 96 dB (A)≤CNE<101 dB (A) group. The results suggest that the rs2763979 locus of the HSP70 genes may be associated with susceptibility to NIHL in Chinese individuals, and other HSP70 genes may also be susceptibility genes for NIHL, but the results must be further replicated in additional independent sample sets. Public Library of Science 2017-02-09 /pmc/articles/PMC5300111/ /pubmed/28182740 http://dx.doi.org/10.1371/journal.pone.0171722 Text en © 2017 Li et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Li, Yanhong
Yu, Shanfa
Gu, Guizhen
Chen, Guoshun
Zheng, Yuxin
Jiao, Jie
Zhou, Wenhui
Wu, Hui
Zhang, Zengrui
Zhang, Huanling
He, Lihua
Yang, Qiuyue
Xu, Xiangrong
Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study
title Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study
title_full Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study
title_fullStr Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study
title_full_unstemmed Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study
title_short Polymorphisms of heat shock protein 70 genes (HSPA1A, HSPA1B and HSPA1L) and susceptibility of noise-induced hearing loss in a Chinese population: A case-control study
title_sort polymorphisms of heat shock protein 70 genes (hspa1a, hspa1b and hspa1l) and susceptibility of noise-induced hearing loss in a chinese population: a case-control study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300111/
https://www.ncbi.nlm.nih.gov/pubmed/28182740
http://dx.doi.org/10.1371/journal.pone.0171722
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