Cargando…

Investigation of the In Vitro and In Vivo efficiency of RM-532-105, a 17β-hydroxysteroid dehydrogenase type 3 inhibitor, in LAPC-4 prostate cancer cell and tumor models

In the fight against androgen-sensitive prostate cancer, the enzyme 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) is an attractive therapeutic target considering its key role in the formation of androgenic steroids. In this study, we attempted to assess the in vivo efficacy of the compound RM-5...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kenmogne, Lucie Carolle, Roy, Jenny, Maltais, René, Rouleau, Mélanie, Neveu, Bertrand, Pouliot, Frédéric, Poirier, Donald
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2017
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300232/ https://www.ncbi.nlm.nih.gov/pubmed/28182747 http://dx.doi.org/10.1371/journal.pone.0171871

Ejemplares similares

The Aminosteroid Derivative RM-133 Shows In Vitro and In Vivo Antitumor Activity in Human Ovarian and Pancreatic Cancers
por: Kenmogne, Lucie Carolle, et al.
Publicado: (2015)

Chemical Synthesis and Biological Evaluation of 3-Substituted Estrone/Estradiol Derivatives as 17β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors Acting via a Reverse Orientation of the Natural Substrate Estrone
por: Ngueta, Adrien Djiemeny, et al.
Publicado: (2023)

Synthesis of 5α-Androstane-17-spiro-δ-lactones with a 3-Keto, 3-Hydroxy, 3-Spirocarbamate or 3-Spiromorpholinone as Inhibitors of 17β-Hydroxysteroid Dehydrogenases
por: Djigoué, Guy Bertrand, et al.
Publicado: (2013)

Estrogen and androgen-converting enzymes 17β-hydroxysteroid dehydrogenase and their involvement in cancer: with a special focus on 17β-hydroxysteroid dehydrogenase type 1, 2, and breast cancer
por: Hilborn, Erik, et al.
Publicado: (2017)

Glioblastoma cells express crucial enzymes involved in androgen synthesis: 3β‐hydroxysteroid dehydrogenase, 17‐20α‐hydroxylase, 17β‐hydroxysteroid dehydrogenase and 5α‐reductase
por: Mondragón, Jose Antonio, et al.
Publicado: (2021)

Interference of Paraben Compounds with Estrogen Metabolism by Inhibition of 17β-Hydroxysteroid Dehydrogenases
por: Engeli, Roger T., et al.
Publicado: (2017)

Structural basis of lipid-droplet localization of 17-beta-hydroxysteroid dehydrogenase 13
por: Liu, Shenping, et al.
Publicado: (2023)

Preparation of 16β-Estradiol Derivative Libraries as Bisubstrate Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 Using the Multidetachable Sulfamate Linker
por: Bérubé, Marie, et al.
Publicado: (2010)

Characterization of 17α-hydroxysteroid dehydrogenase activity (17α-HSD) and its involvement in the biosynthesis of epitestosterone
por: Bellemare, Véronique, et al.
Publicado: (2005)

Dimerization and enzymatic activity of fungal 17β-hydroxysteroid dehydrogenase from the short-chain dehydrogenase/reductase superfamily
por: Kristan, Katja, et al.
Publicado: (2005)

Expression and localization of estrogenic type 12 17β-hydroxysteroid dehydrogenase in the cynomolgus monkey
por: Liu, Hong, et al.
Publicado: (2007)

Interactions of 17β-Hydroxysteroid Dehydrogenase Type 10 and Cyclophilin D in Alzheimer's Disease
por: Kristofikova, Zdenka, et al.
Publicado: (2020)

Induction of Endoplasmic Reticulum Stress-Mediated Apoptosis by Aminosteroid RM-581 Efficiently Blocks the Growth of PC-3 Cancer Cells and Tumors Resistant or Not to Docetaxel
por: Maltais, René, et al.
Publicado: (2021)

Aminosteroid RM-581 Decreases Cell Proliferation of All Breast Cancer Molecular Subtypes, Alone and in Combination with Breast Cancer Treatments
por: Burguin, Anna, et al.
Publicado: (2023)

Hydroxybenzothiazoles as New Nonsteroidal Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 1 (17β-HSD1)
por: Spadaro, Alessandro, et al.
Publicado: (2012)

11β-Hydroxysteroid Dehydrogenase 2 in Preeclampsia
por: Kosicka, Katarzyna, et al.
Publicado: (2016)

Microbial Hydroxysteroid Dehydrogenases: From Alpha to Omega
por: Doden, Heidi L., et al.
Publicado: (2021)

17β-Hydroxysteroid Dehydrogenase Type 2 Expression Is Induced by Androgen Signaling in Endometrial Cancer
por: Hashimoto, Chiaki, et al.
Publicado: (2018)

SUN-159 17-beta Hydroxysteroid Dehydrogenase 3 Deficiency in 1 Month Old Infant
por: Mathew, Deepa, et al.
Publicado: (2020)

Substituted Aryl Benzylamines as Potent and Selective Inhibitors of 17β-Hydroxysteroid Dehydrogenase Type 3
por: Vicker, Nigel, et al.
Publicado: (2021)

A Targeted-Covalent Inhibitor of 17β-HSD1 Blocks Two Estrogen-Biosynthesis Pathways: In Vitro (Metabolism) and In Vivo (Xenograft) Studies in T-47D Breast Cancer Models
por: Poirier, Donald, et al.
Publicado: (2021)

3-Hydroxyacyl-CoA and Alcohol Dehydrogenase Activities of Mitochondrial Type 10 17β-Hydroxysteroid Dehydrogenase in Neurodegeneration Study
por: He, Xue-Ying, et al.
Publicado: (2022)

Luteal 3beta-hydroxysteroid dehydrogenase and 20alpha-hydroxysteroid dehydrogenase activities in the rat corpus luteum of pseudopregnancy: Effect of the deciduoma reaction
por: Clementi, Marisa A, et al.
Publicado: (2004)

17β-Hydroxysteroid dehydrogenases involved in local oestrogen synthesis have prognostic significance in breast cancer
por: Gunnarsson, C, et al.
Publicado: (2005)

Immunoexpression of aromatase cytochrome P450 and 17β-hydroxysteroid dehydrogenase in women’s ovaries after menopause
por: Brodowska, Agnieszka, et al.
Publicado: (2014)

Potential Antiosteoporotic Natural Product Lead Compounds That Inhibit 17β-Hydroxysteroid Dehydrogenase Type 2
por: Vuorinen, Anna, et al.
Publicado: (2017)

Hydroxysteroid 17-Beta Dehydrogenase 6 Is a Prognostic Biomarker and Correlates with Immune Infiltrates in Hepatocellular Carcinoma
por: Wu, Min, et al.
Publicado: (2021)

11β-Hydroxysteroid Dehydrogenases and Hypertension in the Metabolic Syndrome
por: Bailey, Matthew A.
Publicado: (2017)

Genomic data on breast cancer transcript profile modulation by 17beta-hydroxysteroid dehydrogenase type 1 and 17-beta-estradiol
por: Aka, Juliette A., et al.
Publicado: (2016)

Very-long-chain fatty acid metabolic capacity of 17-beta-hydroxysteroid dehydrogenase type 12 (HSD17B12) promotes replication of hepatitis C virus and related flaviviruses
por: Mohamed, Bassim, et al.
Publicado: (2020)

The increased ratio of 11β-hydroxysteroid dehydrogenase type 1 versus 11β-hydroxysteroid dehydrogenase type 2 in chronic periodontitis irrespective of obesity
por: Nakata, Takaya, et al.
Publicado: (2016)

Species Used for Drug Testing Reveal Different Inhibition Susceptibility for 17beta-Hydroxysteroid Dehydrogenase Type 1
por: Möller, Gabriele, et al.
Publicado: (2010)

17beta-hydroxysteroid dehydrogenase type 1 modulates breast cancer protein profile and impacts cell migration
por: Aka, Juliette A, et al.
Publicado: (2012)

Ligand-Based Pharmacophore Modeling and Virtual Screening for the Discovery of Novel 17β-Hydroxysteroid Dehydrogenase 2 Inhibitors
por: Vuorinen, Anna, et al.
Publicado: (2014)

Complexities of gender assignment in 17β-hydroxysteroid dehydrogenase type 3 deficiency: is there a role for early orchiectomy?
por: Chuang, Janet, et al.
Publicado: (2013)

Overexpression of 17β-hydroxysteroid dehydrogenase type 10 increases pheochromocytoma cell growth and resistance to cell death
por: Carlson, Emily A, et al.
Publicado: (2015)

Vitamin K2 Inhibits Hepatocellular Carcinoma Cell Proliferation by Binding to 17β-Hydroxysteroid Dehydrogenase 4
por: Lu, Xin, et al.
Publicado: (2021)

Phosphorylation of 17β-hydroxysteroid dehydrogenase 13 at serine 33 attenuates nonalcoholic fatty liver disease in mice
por: Su, Wen, et al.
Publicado: (2022)

Infantile Neurodegeneration Results from Mutants of 17β-Hydroxysteroid Dehydrogenase Type 10 Rather Than Aβ-Binding Alcohol Dehydrogenase
por: He, Xue-Ying, et al.
Publicado: (2023)

Adrenal morphology and hydroxysteroid dehydrogenase enzymes in normal and intersex goats
por: Basrur, Parvathi K, et al.
Publicado: (1969)

Cannot write session to /tmp/vufind_sessions/sess_kj988c50r47134b0i7rcbtibb5