Prevention of Remifentanil Induced Postoperative Hyperalgesia by Dexmedetomidine via Regulating the Trafficking and Function of Spinal NMDA Receptors as well as PKC and CaMKII Level In Vivo and In Vitro

Remifentanil-induced secondary hyperalgesia has been demonstrated in both animal experiments and clinical trials. Enhancement of N-methyl-D-aspartate (NMDA) receptor trafficking as well as protein kinase C (PKC) and calmodulin-dependent protein kinase II (CaMKII) have been reported to be involved in...

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Detalles Bibliográficos
Autores principales: Yuan, Yuan, Sun, Zhe, Chen, Yi, Zheng, Yuxin, Xie, Ke-liang, He, Ying, Wang, Zhifen, Wang, Guo-lin, Yu, Yong-hao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300256/
https://www.ncbi.nlm.nih.gov/pubmed/28182698
http://dx.doi.org/10.1371/journal.pone.0171348

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