Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation

The Ypd1 phosphorelay protein is a central constituent of fungal two-component signal transduction pathways. Inhibition of Ypd1 in Saccharomyces cerevisiae and Cryptococcus neoformans is lethal due to the sustained activation of the ‘p38-related’ Hog1 stress-activated protein kinase (SAPK). As two-c...

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Detalles Bibliográficos
Autores principales: Day, Alison M., Smith, Deborah A., Ikeh, Mélanie A. C., Haider, Mohammed, Herrero-de-Dios, Carmen M., Brown, Alistair J. P., Morgan, Brian A., Erwig, Lars P., MacCallum, Donna M., Quinn, Janet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300278/
https://www.ncbi.nlm.nih.gov/pubmed/28135328
http://dx.doi.org/10.1371/journal.ppat.1006131

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