Visualizing Changes in Cdkn1c Expression Links Early-Life Adversity to Imprint Mis-regulation in Adults

Imprinted genes are regulated according to parental origin and can influence embryonic growth and metabolism and confer disease susceptibility. Here, we designed sensitive allele-specific reporters to non-invasively monitor imprinted Cdkn1c expression in mice and showed that expression was modulated...

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Detalles Bibliográficos
Autores principales: Van de Pette, Mathew, Abbas, Allifia, Feytout, Amelie, McNamara, Gráinne, Bruno, Ludovica, To, Wilson K., Dimond, Andrew, Sardini, Alessandro, Webster, Zoe, McGinty, James, Paul, Eleanor J., Ungless, Mark A., French, Paul M.W., Withers, Dominic J., Uren, Anthony, Ferguson-Smith, Anne C., Merkenschlager, Matthias, John, Rosalind M., Fisher, Amanda G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5300902/
https://www.ncbi.nlm.nih.gov/pubmed/28147266
http://dx.doi.org/10.1016/j.celrep.2017.01.010

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