RNAi-mediated knockdown of mouse melanocortin-4 receptor in vitro and in vivo, using an siRNA expression construct based on the mir-187 precursor

RNA interference (RNAi) is a powerful tool for the study of gene function in mammalian systems, including transgenic mice. Here, we report a gene knockdown system based on the human mir-187 precursor. We introduced small interfering RNA (siRNA) sequences against the mouse melanocortin-4 receptor (mM...

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Detalles Bibliográficos
Autores principales: Kato, Minoru, Huang, Yi-Ying, Matsuo, Mina, Takashina, Yoko, Sasaki, Kazuyo, Horai, Yasushi, Juni, Aya, Kamijo, Shin-Ichi, Saigo, Kaoru, Ui-Tei, Kumiko, Tei, Hajime
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Japanese Association for Laboratory Animal Science 2016
Materias:
Original
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301000/
https://www.ncbi.nlm.nih.gov/pubmed/27725374
http://dx.doi.org/10.1538/expanim.16-0065

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