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Presentation of Autoantigen in Peripheral Lymph Nodes Is Sufficient for Priming Autoreactive CD8(+) T Cells

Peripheral tolerance is an important mechanism by which the immune system can guarantee a second line of defense against autoreactive T and B cells. One autoimmune disease that is related to a break of peripheral tolerance is diabetes mellitus type 1. Using the RIP-GP mouse model, we analyzed the ro...

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Detalles Bibliográficos
Autores principales:	Honke, Nadine, Shaabani, Namir, Teijaro, John R., Christen, Urs, Hardt, Cornelia, Bezgovsek, Judith, Lang, Philipp A., Lang, Karl S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301005/ https://www.ncbi.nlm.nih.gov/pubmed/28239381 http://dx.doi.org/10.3389/fimmu.2017.00113

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