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B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity
Myasthenia gravis (MG) is a T cell-dependent, B cell-mediated disease. The mechanisms for loss of self-tolerance in this disease are not well understood, and recently described regulatory B cell (Breg) subsets have not been thoroughly investigated. B10 cells are a subset of Bregs identified by the p...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2017
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301008/ https://www.ncbi.nlm.nih.gov/pubmed/28239367 http://dx.doi.org/10.3389/fneur.2017.00034 |
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author | Yi, John S. Russo, Melissa A. Massey, Janice M. Juel, Vern Hobson-Webb, Lisa D. Gable, Karissa Raja, Shruti M. Balderson, Kristina Weinhold, Kent J. Guptill, Jeffrey T. |
author_facet | Yi, John S. Russo, Melissa A. Massey, Janice M. Juel, Vern Hobson-Webb, Lisa D. Gable, Karissa Raja, Shruti M. Balderson, Kristina Weinhold, Kent J. Guptill, Jeffrey T. |
author_sort | Yi, John S. |
collection | PubMed |
description | Myasthenia gravis (MG) is a T cell-dependent, B cell-mediated disease. The mechanisms for loss of self-tolerance in this disease are not well understood, and recently described regulatory B cell (Breg) subsets have not been thoroughly investigated. B10 cells are a subset of Bregs identified by the production of the immunosuppressive cytokine, interleukin-10 (IL-10). B10 cells are known to strongly inhibit B- and T-cell inflammatory responses in animal models and are implicated in human autoimmunity. In this study, we examined quantitative and qualitative aspects of B10 cells in acetylcholine receptor autoantibody positive MG (AChR-MG) patients and healthy controls. We observed reduced B10 cell frequencies in AChR-MG patients, which inversely correlated with disease severity. Disease severity also affected the function of B10 cells, as B10 cells in the moderate/severe group of MG patients were less effective in suppressing CD4 T-cell proliferation. These results suggest that B10 cell frequencies may be a useful biomarker of disease severity, and therapeutics designed to restore B10 cell frequencies could hold promise as a treatment for this disease through restoration of self-tolerance. |
format | Online Article Text |
id | pubmed-5301008 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-53010082017-02-24 B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity Yi, John S. Russo, Melissa A. Massey, Janice M. Juel, Vern Hobson-Webb, Lisa D. Gable, Karissa Raja, Shruti M. Balderson, Kristina Weinhold, Kent J. Guptill, Jeffrey T. Front Neurol Neuroscience Myasthenia gravis (MG) is a T cell-dependent, B cell-mediated disease. The mechanisms for loss of self-tolerance in this disease are not well understood, and recently described regulatory B cell (Breg) subsets have not been thoroughly investigated. B10 cells are a subset of Bregs identified by the production of the immunosuppressive cytokine, interleukin-10 (IL-10). B10 cells are known to strongly inhibit B- and T-cell inflammatory responses in animal models and are implicated in human autoimmunity. In this study, we examined quantitative and qualitative aspects of B10 cells in acetylcholine receptor autoantibody positive MG (AChR-MG) patients and healthy controls. We observed reduced B10 cell frequencies in AChR-MG patients, which inversely correlated with disease severity. Disease severity also affected the function of B10 cells, as B10 cells in the moderate/severe group of MG patients were less effective in suppressing CD4 T-cell proliferation. These results suggest that B10 cell frequencies may be a useful biomarker of disease severity, and therapeutics designed to restore B10 cell frequencies could hold promise as a treatment for this disease through restoration of self-tolerance. Frontiers Media S.A. 2017-02-10 /pmc/articles/PMC5301008/ /pubmed/28239367 http://dx.doi.org/10.3389/fneur.2017.00034 Text en Copyright © 2017 Yi, Russo, Massey, Juel, Hobson-Webb, Gable, Raja, Balderson, Weinhold and Guptill. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Yi, John S. Russo, Melissa A. Massey, Janice M. Juel, Vern Hobson-Webb, Lisa D. Gable, Karissa Raja, Shruti M. Balderson, Kristina Weinhold, Kent J. Guptill, Jeffrey T. B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity |
title | B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity |
title_full | B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity |
title_fullStr | B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity |
title_full_unstemmed | B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity |
title_short | B10 Cell Frequencies and Suppressive Capacity in Myasthenia Gravis Are Associated with Disease Severity |
title_sort | b10 cell frequencies and suppressive capacity in myasthenia gravis are associated with disease severity |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301008/ https://www.ncbi.nlm.nih.gov/pubmed/28239367 http://dx.doi.org/10.3389/fneur.2017.00034 |
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