Gastrointestinal Stromal Tumour with Synchronous Bone Metastases: A Case Report and Literature Review

Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours of the digestive tract, derived from Cajal interstitial cells. Bone metastases are very rare, and there is no consensus regarding their treatment. Here, we present the unusual case of a 66-year-old man with a gastric GIST with synchron...

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Detalles Bibliográficos
Autores principales: Rochigneux, Philippe, Mescam-Mancini, Lénaig, Perrot, Delphine, Bories, Erwan, Moureau-Zabotto, Laurence, Sarran, Anthony, Guiramand, Jérôme, Bertucci, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301111/
https://www.ncbi.nlm.nih.gov/pubmed/28203166
http://dx.doi.org/10.1159/000455188
Descripción
Sumario:Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours of the digestive tract, derived from Cajal interstitial cells. Bone metastases are very rare, and there is no consensus regarding their treatment. Here, we present the unusual case of a 66-year-old man with a gastric GIST with synchronous bone and liver metastases, fully documented at the pathological and molecular levels with a KIT exon 11 mutation. After 9 months of imatinib, the scanner showed a 33% partial response of target lesions. We also review the literature and describe the characteristics, treatment, and outcome of all cases previously reported.

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