Gastrointestinal Stromal Tumour with Synchronous Bone Metastases: A Case Report and Literature Review

Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours of the digestive tract, derived from Cajal interstitial cells. Bone metastases are very rare, and there is no consensus regarding their treatment. Here, we present the unusual case of a 66-year-old man with a gastric GIST with synchron...

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Autores principales: Rochigneux, Philippe, Mescam-Mancini, Lénaig, Perrot, Delphine, Bories, Erwan, Moureau-Zabotto, Laurence, Sarran, Anthony, Guiramand, Jérôme, Bertucci, François
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301111/
https://www.ncbi.nlm.nih.gov/pubmed/28203166
http://dx.doi.org/10.1159/000455188
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author Rochigneux, Philippe
Mescam-Mancini, Lénaig
Perrot, Delphine
Bories, Erwan
Moureau-Zabotto, Laurence
Sarran, Anthony
Guiramand, Jérôme
Bertucci, François
author_facet Rochigneux, Philippe
Mescam-Mancini, Lénaig
Perrot, Delphine
Bories, Erwan
Moureau-Zabotto, Laurence
Sarran, Anthony
Guiramand, Jérôme
Bertucci, François
author_sort Rochigneux, Philippe
collection PubMed
description Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours of the digestive tract, derived from Cajal interstitial cells. Bone metastases are very rare, and there is no consensus regarding their treatment. Here, we present the unusual case of a 66-year-old man with a gastric GIST with synchronous bone and liver metastases, fully documented at the pathological and molecular levels with a KIT exon 11 mutation. After 9 months of imatinib, the scanner showed a 33% partial response of target lesions. We also review the literature and describe the characteristics, treatment, and outcome of all cases previously reported.
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spelling pubmed-53011112017-02-15 Gastrointestinal Stromal Tumour with Synchronous Bone Metastases: A Case Report and Literature Review Rochigneux, Philippe Mescam-Mancini, Lénaig Perrot, Delphine Bories, Erwan Moureau-Zabotto, Laurence Sarran, Anthony Guiramand, Jérôme Bertucci, François Case Rep Oncol Case Report Gastrointestinal stromal tumours (GISTs) are mesenchymal tumours of the digestive tract, derived from Cajal interstitial cells. Bone metastases are very rare, and there is no consensus regarding their treatment. Here, we present the unusual case of a 66-year-old man with a gastric GIST with synchronous bone and liver metastases, fully documented at the pathological and molecular levels with a KIT exon 11 mutation. After 9 months of imatinib, the scanner showed a 33% partial response of target lesions. We also review the literature and describe the characteristics, treatment, and outcome of all cases previously reported. S. Karger AG 2017-01-17 /pmc/articles/PMC5301111/ /pubmed/28203166 http://dx.doi.org/10.1159/000455188 Text en Copyright © 2017 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Rochigneux, Philippe
Mescam-Mancini, Lénaig
Perrot, Delphine
Bories, Erwan
Moureau-Zabotto, Laurence
Sarran, Anthony
Guiramand, Jérôme
Bertucci, François
Gastrointestinal Stromal Tumour with Synchronous Bone Metastases: A Case Report and Literature Review
title Gastrointestinal Stromal Tumour with Synchronous Bone Metastases: A Case Report and Literature Review
title_full Gastrointestinal Stromal Tumour with Synchronous Bone Metastases: A Case Report and Literature Review
title_fullStr Gastrointestinal Stromal Tumour with Synchronous Bone Metastases: A Case Report and Literature Review
title_full_unstemmed Gastrointestinal Stromal Tumour with Synchronous Bone Metastases: A Case Report and Literature Review
title_short Gastrointestinal Stromal Tumour with Synchronous Bone Metastases: A Case Report and Literature Review
title_sort gastrointestinal stromal tumour with synchronous bone metastases: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301111/
https://www.ncbi.nlm.nih.gov/pubmed/28203166
http://dx.doi.org/10.1159/000455188
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