Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis

Both long-term administration of immunosuppressive agents and chronic inflammatory conditions, such as autoimmune disease, could be risk factors for the development of cutaneous squamous cell carcinoma (cSCC). In this report, we present a case of recurrent multiple cSCC on the scalp in a patient wit...

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Autores principales: Sato, Yota, Fujimura, Taku, Kambayashi, Yumi, Tsukada, Akira, Hidaka, Takanori, Tanita, Kayo, Haga, Takahiro, Hashimoto, Akira, Aiba, Setsuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: S. Karger AG 2017
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301118/
https://www.ncbi.nlm.nih.gov/pubmed/28203172
http://dx.doi.org/10.1159/000456001
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author Sato, Yota
Fujimura, Taku
Kambayashi, Yumi
Tsukada, Akira
Hidaka, Takanori
Tanita, Kayo
Haga, Takahiro
Hashimoto, Akira
Aiba, Setsuya
author_facet Sato, Yota
Fujimura, Taku
Kambayashi, Yumi
Tsukada, Akira
Hidaka, Takanori
Tanita, Kayo
Haga, Takahiro
Hashimoto, Akira
Aiba, Setsuya
author_sort Sato, Yota
collection PubMed
description Both long-term administration of immunosuppressive agents and chronic inflammatory conditions, such as autoimmune disease, could be risk factors for the development of cutaneous squamous cell carcinoma (cSCC). In this report, we present a case of recurrent multiple cSCC on the scalp in a patient with juvenile dermatomyositis who had been administered cyclosporine and Predonine since she was a 1-year-old infant. Interestingly, immunohistochemical staining revealed IL-17-producing cells adjacent to IL-17R-expressing atypical keratinocytes. Our present case suggested that IL-17/IL-17R signaling might contribute to the carcinogenesis of cSCC.
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spelling pubmed-53011182017-02-15 Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis Sato, Yota Fujimura, Taku Kambayashi, Yumi Tsukada, Akira Hidaka, Takanori Tanita, Kayo Haga, Takahiro Hashimoto, Akira Aiba, Setsuya Case Rep Oncol Case Report Both long-term administration of immunosuppressive agents and chronic inflammatory conditions, such as autoimmune disease, could be risk factors for the development of cutaneous squamous cell carcinoma (cSCC). In this report, we present a case of recurrent multiple cSCC on the scalp in a patient with juvenile dermatomyositis who had been administered cyclosporine and Predonine since she was a 1-year-old infant. Interestingly, immunohistochemical staining revealed IL-17-producing cells adjacent to IL-17R-expressing atypical keratinocytes. Our present case suggested that IL-17/IL-17R signaling might contribute to the carcinogenesis of cSCC. S. Karger AG 2017-01-20 /pmc/articles/PMC5301118/ /pubmed/28203172 http://dx.doi.org/10.1159/000456001 Text en Copyright © 2017 by S. Karger AG, Basel http://creativecommons.org/licenses/by-nc/4.0/ This article is licensed under the Creative Commons Attribution-NonCommercial-4.0 International License (CC BY-NC) (http://www.karger.com/Services/OpenAccessLicense). Usage and distribution for commercial purposes requires written permission.
spellingShingle Case Report
Sato, Yota
Fujimura, Taku
Kambayashi, Yumi
Tsukada, Akira
Hidaka, Takanori
Tanita, Kayo
Haga, Takahiro
Hashimoto, Akira
Aiba, Setsuya
Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis
title Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis
title_full Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis
title_fullStr Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis
title_full_unstemmed Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis
title_short Recurrent Multiple Squamous Cell Carcinomas on the Scalp in a Patient with Juvenile Dermatomyositis
title_sort recurrent multiple squamous cell carcinomas on the scalp in a patient with juvenile dermatomyositis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301118/
https://www.ncbi.nlm.nih.gov/pubmed/28203172
http://dx.doi.org/10.1159/000456001
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