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Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization

The niacin receptor HCA2 is implicated in controlling inflammatory host responses with yet poorly understood mechanistic basis. We previously reported that HCA2 in A431 epithelial cells transduced Gβγ-protein kinase C- and Gβγ-metalloproteinase/EGFR-dependent MAPK/ERK signaling cascades. Here, we in...

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Detalles Bibliográficos
Autores principales:	Shi, Ying, Lai, Xiangru, Ye, Lingyan, Chen, Keqiang, Cao, Zheng, Gong, Wanghua, Jin, Lili, Wang, Chunyan, Liu, Mingyong, Liao, Yuan, Wang, Ji Ming, Zhou, Naiming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301212/ https://www.ncbi.nlm.nih.gov/pubmed/28186140 http://dx.doi.org/10.1038/srep42279

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