Cargando…

Activated niacin receptor HCA2 inhibits chemoattractant-mediated macrophage migration via Gβγ/PKC/ERK1/2 pathway and heterologous receptor desensitization

The niacin receptor HCA2 is implicated in controlling inflammatory host responses with yet poorly understood mechanistic basis. We previously reported that HCA2 in A431 epithelial cells transduced Gβγ-protein kinase C- and Gβγ-metalloproteinase/EGFR-dependent MAPK/ERK signaling cascades. Here, we in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shi, Ying, Lai, Xiangru, Ye, Lingyan, Chen, Keqiang, Cao, Zheng, Gong, Wanghua, Jin, Lili, Wang, Chunyan, Liu, Mingyong, Liao, Yuan, Wang, Ji Ming, Zhou, Naiming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301212/ https://www.ncbi.nlm.nih.gov/pubmed/28186140 http://dx.doi.org/10.1038/srep42279

Ejemplares similares

Structural insights into the human niacin receptor HCA2-G(i) signalling complex
por: Yang, Yang, et al.
Publicado: (2023)

The Contribution of Chemoattractant GPCRs, Formylpeptide Receptors, to Inflammation and Cancer
por: Liang, Weiwei, et al.
Publicado: (2020)

The Role of Chemoattractant Receptors in Shaping the Tumor Microenvironment
por: Zhou, Jiamin, et al.
Publicado: (2014)

μ-Opioid receptor desensitization: homologous or heterologous?
por: Llorente, Javier, et al.
Publicado: (2012)

Niacin Activates the PI3K/Akt Cascade via PKC- and EGFR-Transactivation-Dependent Pathways through Hydroxyl-Carboxylic Acid Receptor 2
por: Sun, Huawang, et al.
Publicado: (2014)

Sequestration of Gβγ by deubiquitinated arrestins into the nucleus as a novel desensitization mechanism of G protein–coupled receptors
por: Min, Xiao, et al.
Publicado: (2023)

High Glucose Promotes Human Glioblastoma Cell Growth by Increasing the Expression and Function of Chemoattractant and Growth Factor Receptors()
por: Bao, Zhiyao, et al.
Publicado: (2019)

Opiates Transdeactivate Chemokine Receptors: δ and μ Opiate Receptor–mediated Heterologous Desensitization
por: Grimm, M.C., et al.
Publicado: (1998)

The G-Protein-Coupled Chemoattractant Receptor Fpr2 Exacerbates High Glucose-Mediated Proinflammatory Responses of Müller Glial Cells
por: Yu, Ying, et al.
Publicado: (2017)

Screening of Different Organs of Rats for HCA2 Receptor mRNA
por: Shomali, Tahoora, et al.
Publicado: (2014)

Production of Hydroxycarboxylic Acid Receptor 3 (HCA(3)) Ligands by Bifidobacterium
por: Sakurai, Takuma, et al.
Publicado: (2021)

Chromosomal Location of HCA1 and HCA2, Hybrid Chlorosis Genes in Rice
por: Ichitani, Katsuyuki, et al.
Publicado: (2012)

Allosteric Modulation of Chemoattractant Receptors
por: Allegretti, Marcello, et al.
Publicado: (2016)

α(1B)-Adrenergic Receptors Differentially Associate with Rab Proteins during Homologous and Heterologous Desensitization
por: Castillo-Badillo, Jean A., et al.
Publicado: (2015)

Expression of HCA2 Receptors in Femoral Epiphysis and Metaphysis of Rats with Dexamethasone-Induced Osteoporosis
por: Shomali, Tahoora, et al.
Publicado: (2016)

Formylpeptide Receptors Mediate Rapid Neutrophil Mobilization to Accelerate Wound Healing
por: Liu, Mingyong, et al.
Publicado: (2014)

Formylpeptide receptors are critical for rapid neutrophil mobilization in host defense against Listeria monocytogenes
por: Liu, Mingyong, et al.
Publicado: (2012)

HCaRG/COMMD5 inhibits ErbB receptor-driven renal cell carcinoma
por: Matsuda, Hiroyuki, et al.
Publicado: (2017)

Induction of HCA587-Specific Antitumor Immunity with HCA587 Protein Formulated with CpG and ISCOM in Mice
por: Chen, Juanjuan, et al.
Publicado: (2012)

Editorial: Atypical Functions of Leukocyte Chemoattractant Receptors
por: Rodríguez-Fernández, José Luis, et al.
Publicado: (2020)

PKCβII acts downstream of chemoattractant receptors and mTORC2 to regulate cAMP production and myosin II activity in neutrophils
por: Liu, Lunhua, et al.
Publicado: (2014)

Fast desensitization of acetylcholine receptors induced by a spider toxin
por: Pan, Na Clara, et al.
Publicado: (2021)

Internalization and desensitization of adenosine receptors
por: Klaasse, Elisabeth C., et al.
Publicado: (2007)

Odorant Receptor Desensitization in Insects
por: Guo, Hao, et al.
Publicado: (2017)

Pathways for nicotinic receptor desensitization
por: Auerbach, Anthony
Publicado: (2020)

Non-Myeloid Cells are Major Contributors to Innate Immune Responses via Production of Monocyte Chemoattractant Protein-1/CCL2
por: Yoshimura, Teizo, et al.
Publicado: (2014)

GPCR-mediated PLCβγ/PKCβ/PKD signaling pathway regulates the cofilin phosphatase slingshot 2 in neutrophil chemotaxis
por: Xu, Xuehua, et al.
Publicado: (2015)

Structural and Energetic Insights Into the Interaction of Niacin With the GPR109A Receptor
por: Adepu, Kiran Kumar, et al.
Publicado: (2021)

The G‐protein‐coupled chemoattractant receptor Fpr2 exacerbates neuroglial dysfunction and angiogenesis in diabetic retinopathy
por: Yu, Ying, et al.
Publicado: (2020)

Updates on Antiobesity Effect of Garcinia Origin (−)-HCA
por: Chuah, Li Oon, et al.
Publicado: (2013)

Hypertension-related, calcium-regulated gene (HCaRG/COMMD5) and kidney diseases: HCaRG accelerates tubular repair
por: Matsuda, Hiroyuki, et al.
Publicado: (2014)

Niacin in Maize
por: Burkholder, Paul R., et al.
Publicado: (1944)

Dietary Niacin Supplementation Suppressed Hepatic Lipid Accumulation in Rabbits
por: Liu, Lei, et al.
Publicado: (2016)

Inhibition of Transient Receptor Potential Melastatin 3 ion channels by G-protein βγ subunits
por: Badheka, Doreen, et al.
Publicado: (2017)

CB(1) Cannabinoid Receptors Stimulate Gβγ-GRK2-Mediated FAK Phosphorylation at Tyrosine 925 to Regulate ERK Activation Involving Neuronal Focal Adhesions
por: Dalton, George D., et al.
Publicado: (2020)

Niacin regulates apolipoprotein M expression via liver X receptor-α
por: Yang, Liu, et al.
Publicado: (2019)

Steroidogenesis and early response gene expression in MA-10 Leydig tumor cells following heterologous receptor down-regulation and cellular desensitization
por: Chen, Tsuey-Ming, et al.
Publicado: (2016)

Neutrophil chemoattractant receptors in health and disease: double-edged swords
por: Metzemaekers, Mieke, et al.
Publicado: (2020)

Nicotinic acid suppresses sebaceous lipogenesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA(2))
por: Markovics, Arnold, et al.
Publicado: (2019)

The Lactate Receptor HCA(1) Is Present in the Choroid Plexus, the Tela Choroidea, and the Neuroepithelial Lining of the Dorsal Part of the Third Ventricle
por: Hadzic, Alena, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_lf3viv736q23trmp30t89pdhpk