Cargando…

Preclinical evaluation of bacterially produced RSV-G protein vaccine: Strong protection against RSV challenge in cotton rat model

In current study, we evaluated the safety and protective efficacy of recombinant unglycosylated RSV G protein ectodomain produced in E. coli (in presence and absence of oil-in-water adjuvant) in a preclinical RSV susceptible cotton rat challenge model compared to formaldehyde inactivated RSV (FI-RSV...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fuentes, Sandra, Klenow, Laura, Golding, Hana, Khurana, Surender
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301242/ https://www.ncbi.nlm.nih.gov/pubmed/28186208 http://dx.doi.org/10.1038/srep42428

Ejemplares similares

Antigenic Fingerprinting following Primary RSV Infection in Young Children Identifies Novel Antigenic Sites and Reveals Unlinked Evolution of Human Antibody Repertoires to Fusion and Attachment Glycoproteins
por: Fuentes, Sandra, et al.
Publicado: (2016)

RSV A2-Based Prefusion F Vaccine Candidates Induce RSV A and RSV B Cross Binding and Neutralizing Antibodies and Provide Protection against RSV A and RSV B Challenge in Preclinical Models
por: Cox, Freek, et al.
Publicado: (2023)

RSV Replication, Transmission, and Disease Are Influenced by the RSV G Protein
por: Bergeron, Harrison C., et al.
Publicado: (2022)

Protective antigenic sites in respiratory syncytial virus G attachment protein outside the central conserved and cysteine noose domains
por: Lee, Jeehyun, et al.
Publicado: (2018)

M Protein-Deficient Respiratory Syncytial Virus (RSV) Vaccine Protects Infant Baboons Against RSV Challenge
por: Welliver, Robert C, et al.
Publicado: (2017)

Is it RSV?
por: Ambrose, Christopher S.
Publicado: (2018)

Correlative outcomes of maternal immunization against RSV in cotton rats
por: Blanco, Jorge C. G., et al.
Publicado: (2022)

Global molecular diversity of RSV – the “INFORM RSV” study
por: Langedijk, Annefleur C., et al.
Publicado: (2020)

Giving RSV some POP(G)
por: Baas, Tracey
Publicado: (2010)

An insect cell derived respiratory syncytial virus (RSV) F nanoparticle vaccine induces antigenic site II antibodies and protects against RSV challenge in cotton rats by active and passive immunization
por: Raghunandan, Rama, et al.
Publicado: (2014)

Chimeric Measles Virus (MV/RSV), Having Ectodomains of Respiratory Syncytial Virus (RSV) F and G Proteins Instead of Measles Envelope Proteins, Induced Protective Antibodies against RSV
por: Sawada, Akihito, et al.
Publicado: (2021)

Bovine IgG Prevents Experimental Infection With RSV and Facilitates Human T Cell Responses to RSV
por: Nederend, Maaike, et al.
Publicado: (2020)

Autoreactivity of Broadly Neutralizing Influenza Human Antibodies to Human Tissues and Human Proteins
por: Khurana, Surender, et al.
Publicado: (2020)

2770. Intrapulmonary Vaccination with an M Protein-Deficient Respiratory Syncytial Virus (RSV) Vaccine Protects Infant Baboons Against an RSV Challenge
por: Welliver, Robert C, et al.
Publicado: (2019)

Pre-fusion RSV F strongly boosts pre-fusion specific neutralizing responses in cattle pre-exposed to bovine RSV
por: Steff, Ann-Muriel, et al.
Publicado: (2017)

An outbreak of RSV infections in a neonatology clinic during the RSV-season
por: Vakrilova, Liliya, et al.
Publicado: (2021)

Protective and dysregulated T cell immunity in RSV infection()
por: Openshaw, Peter J, et al.
Publicado: (2013)

2592. Lung Function as an Indicator of Vaccine Enhanced RSV Disease in Cotton Rats
por: Jones, Crystal, et al.
Publicado: (2019)

Sequence variability of the respiratory syncytial virus (RSV) fusion gene among contemporary and historical genotypes of RSV/A and RSV/B
por: Hause, Anne M., et al.
Publicado: (2017)

Combination Therapy Using Monoclonal Antibodies against Respiratory Syncytial Virus (RSV) G Glycoprotein Protects from RSV Disease in BALB/c Mice
por: Caidi, Hayat, et al.
Publicado: (2012)

1633. Willingness to receive maternal RSV vaccine and infant monoclonal RSV antibody
por: Gidengil, Courtney, et al.
Publicado: (2023)

Correction: Sequence variability of the respiratory syncytial virus (RSV) fusion gene among contemporary and historical genotypes of RSV/A and RSV/B
por: Hause, Anne M., et al.
Publicado: (2017)

Transplacental transfer of maternal respiratory syncytial virus (RSV) antibody and protection against RSV disease in infants in rural Nepal()
por: Chu, Helen Y., et al.
Publicado: (2017)

A Recombinant MVA-Based RSV Vaccine Induces T-Cell and Antibody Responses That Cooperate in the Protection Against RSV Infection
por: Endt, Kathrin, et al.
Publicado: (2022)

Emergency Department Septic Screening in Respiratory Syncytial Virus (RSV) and Non-RSV Bronchiolitis
por: Chee, Chris, et al.
Publicado: (2010)

Prevalent levels of RSV serum neutralizing antibodies in healthy adults outside the RSV-season
por: Van Der Plas, Johan L., et al.
Publicado: (2019)

RSV: perspectives to strengthen the need for protection in all infants
por: Navarro Alonso, Jose Antonio, et al.
Publicado: (2021)

Two RSV Platforms for G, F, or G+F Proteins VLPs
por: Ha, Binh, et al.
Publicado: (2020)

Immunity to RSV in Early-Life
por: Lambert, Laura, et al.
Publicado: (2014)

Severe Rhabdomyolysis Associated With RSV
por: Bender, James, et al.
Publicado: (2017)

Nasal Microbiota in RSV Bronchiolitis
por: Schippa, Serena, et al.
Publicado: (2020)

Respiratory Syncytial Virus (RSV)
por: Walsh, Edward E., et al.
Publicado: (2015)

Socioeconomic Impact of RSV Hospitalization
por: Young, Michal, et al.
Publicado: (2021)

Immunopathology of RSV: An Updated Review
por: Bergeron, Harrison C., et al.
Publicado: (2021)

Clinical severity of RSV bronchiolitis
por: Hussain, Faris, et al.
Publicado: (2022)

Effects of Formalin-Inactivated Respiratory Syncytial Virus (FI-RSV) in the Perinatal Lamb Model of RSV
por: Derscheid, Rachel J., et al.
Publicado: (2013)

Characterisation of RSV Fusion Proteins from South African Patients with RSV Disease, 2019 to 2020
por: Mabilo, Prince, et al.
Publicado: (2022)

The Differences Between RSV and no RSV Acute Bronchiolitis in Hospitalized Infants: A Cross-Sectional Study
por: Christou, Evangelos, et al.
Publicado: (2022)

IgG3 Snitcher of RSV Infections in the Very Young
por: Schepens, Bert, et al.
Publicado: (2017)

Respiratory Syncytial Virus (RSV) Neutralizing Antibodies at Birth Predict Protection from RSV Illness in Infants in the First 3 Months of Life
por: Buchwald, Andrea G, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_u6vcsaeeu1ivtqcqoosc2nj0ia