A new approach to quantification of mAb aggregates using peptide affinity probes

Using mAbs as therapeutic molecules is complicated by the propensity of mAbs to aggregate at elevated concentrations, which can lead to a variety of adverse events in treatment. Here, we describe a proof-of-concept for new methodology to detect and quantify mAb aggregation. Assay development include...

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Detalles Bibliográficos
Autores principales: Cheung, Crystal S. F., Anderson, Kyle W., Patel, Pooja M., Cade, Keale L., Phinney, Karen W., Turko, Illarion V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301252/
https://www.ncbi.nlm.nih.gov/pubmed/28186164
http://dx.doi.org/10.1038/srep42497

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301252/
https://www.ncbi.nlm.nih.gov/pubmed/28186164
http://dx.doi.org/10.1038/srep42497

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