HIF-1α inhibitor echinomycin reduces acute graft-versus-host disease and preserves graft-versus-leukemia effect

BACKGROUND: Acute graft-versus-host disease (aGVHD) remains a major obstacle against favorable clinical outcomes following allogeneic hematopoietic stem cell transplantation (allo-HSCT). T helper cells including Th17 play key roles in aGVHD pathogenesis. Donor regulatory T cell (Tregs) adoptive ther...

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Detalles Bibliográficos
Autores principales: Yao, Yushi, Wang, Lei, Zhou, Jihao, Zhang, Xinyou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301444/
https://www.ncbi.nlm.nih.gov/pubmed/28183349
http://dx.doi.org/10.1186/s12967-017-1132-9

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