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Transplantation in resource-limited setting: using HIV-positive donors for HIV-positive patients
Abstract. Background: A HIV positive-to-positive program was started in South Africa in 2008. The program was started because dialysis is not freely available to everyone, but severely limited and only available to a selected group of patients. Patients and Methods: Between September 2008 and March...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dustri-Verlag Dr. Karl Feistle
2015
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301456/ https://www.ncbi.nlm.nih.gov/pubmed/25725240 http://dx.doi.org/10.5414/CNP83S0039 |
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author | Muller, Elmi |
author_facet | Muller, Elmi |
author_sort | Muller, Elmi |
collection | PubMed |
description | Abstract. Background: A HIV positive-to-positive program was started in South Africa in 2008. The program was started because dialysis is not freely available to everyone, but severely limited and only available to a selected group of patients. Patients and Methods: Between September 2008 and March 2015, 29 patients were transplanted from HIV-positive brain-dead donors at Groote Schuur Hospital transplant team. Donors were either naïve to anti-retroviral therapy or on first line therapy. The recipients were selected to have undetectable plasma HIV type 1 RNA levels and be on a stable antiretroviral regimen. CD4+ T-cell counts of at least 200/mm(3) in last 6 months prior to transplant, with no previous serious opportunistic infections. Results: Survivors in the study were followed for a median of 2.4 years. The rate of patient survival was 84% at 1 year and 74% at 5 years. The corresponding graft survival rate was 93% and 84%. Conclusion: Using HIV-positive donors might resolve some of the problems we are experiencing in getting enough donors for our patients wit ESRD. In the USA the HOPE act was accepted in 2014 and this might now also impact on the use of HIV positive donors elsewhere in the world. |
format | Online Article Text |
id | pubmed-5301456 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Dustri-Verlag Dr. Karl Feistle |
record_format | MEDLINE/PubMed |
spelling | pubmed-53014562017-02-28 Transplantation in resource-limited setting: using HIV-positive donors for HIV-positive patients Muller, Elmi Clin Nephrol Research Article Abstract. Background: A HIV positive-to-positive program was started in South Africa in 2008. The program was started because dialysis is not freely available to everyone, but severely limited and only available to a selected group of patients. Patients and Methods: Between September 2008 and March 2015, 29 patients were transplanted from HIV-positive brain-dead donors at Groote Schuur Hospital transplant team. Donors were either naïve to anti-retroviral therapy or on first line therapy. The recipients were selected to have undetectable plasma HIV type 1 RNA levels and be on a stable antiretroviral regimen. CD4+ T-cell counts of at least 200/mm(3) in last 6 months prior to transplant, with no previous serious opportunistic infections. Results: Survivors in the study were followed for a median of 2.4 years. The rate of patient survival was 84% at 1 year and 74% at 5 years. The corresponding graft survival rate was 93% and 84%. Conclusion: Using HIV-positive donors might resolve some of the problems we are experiencing in getting enough donors for our patients wit ESRD. In the USA the HOPE act was accepted in 2014 and this might now also impact on the use of HIV positive donors elsewhere in the world. Dustri-Verlag Dr. Karl Feistle 2015-03 2015-02-23 /pmc/articles/PMC5301456/ /pubmed/25725240 http://dx.doi.org/10.5414/CNP83S0039 Text en © Dustri-Verlag Dr. K. Feistle http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Muller, Elmi Transplantation in resource-limited setting: using HIV-positive donors for HIV-positive patients |
title | Transplantation in resource-limited setting: using HIV-positive donors for HIV-positive patients |
title_full | Transplantation in resource-limited setting: using HIV-positive donors for HIV-positive patients |
title_fullStr | Transplantation in resource-limited setting: using HIV-positive donors for HIV-positive patients |
title_full_unstemmed | Transplantation in resource-limited setting: using HIV-positive donors for HIV-positive patients |
title_short | Transplantation in resource-limited setting: using HIV-positive donors for HIV-positive patients |
title_sort | transplantation in resource-limited setting: using hiv-positive donors for hiv-positive patients |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301456/ https://www.ncbi.nlm.nih.gov/pubmed/25725240 http://dx.doi.org/10.5414/CNP83S0039 |
work_keys_str_mv | AT mullerelmi transplantationinresourcelimitedsettingusinghivpositivedonorsforhivpositivepatients |