Dimerisation induced formation of the active site and the identification of three metal sites in EAL-phosphodiesterases

The bacterial second messenger cyclic di-3′,5′-guanosine monophosphate (c-di-GMP) is a key regulator of bacterial motility and virulence. As high levels of c-di-GMP are associated with the biofilm lifestyle, c-di-GMP hydrolysing phosphodiesterases (PDEs) have been identified as key targets to aid de...

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Detalles Bibliográficos
Autores principales: Bellini, Dom, Horrell, Sam, Hutchin, Andrew, Phippen, Curtis W., Strange, Richard W., Cai, Yuming, Wagner, Armin, Webb, Jeremy S., Tews, Ivo, Walsh, Martin A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5301497/
https://www.ncbi.nlm.nih.gov/pubmed/28186120
http://dx.doi.org/10.1038/srep42166

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