A novel method for heterocyclic amide–thioamide transformations

In this paper, we introduce a novel and convenient method for the transformation of heterocyclic amides into heteocyclic thioamides. A two-step approach was applied for this transformation: Firstly, we applied a chlorination of the heterocyclic amides to afford the corresponding chloroheterocycles....

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Detalles Bibliográficos
Autores principales: Fathalla, Walid, Ali, Ibrahim A I, Pazdera, Pavel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2017
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302013/
https://www.ncbi.nlm.nih.gov/pubmed/28228858
http://dx.doi.org/10.3762/bjoc.13.20
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author Fathalla, Walid
Ali, Ibrahim A I
Pazdera, Pavel
author_facet Fathalla, Walid
Ali, Ibrahim A I
Pazdera, Pavel
author_sort Fathalla, Walid
collection PubMed
description In this paper, we introduce a novel and convenient method for the transformation of heterocyclic amides into heteocyclic thioamides. A two-step approach was applied for this transformation: Firstly, we applied a chlorination of the heterocyclic amides to afford the corresponding chloroheterocycles. Secondly, the chloroherocycles and N-cyclohexyl dithiocarbamate cyclohexylammonium salt were heated in chloroform for 12 h at 61 °C to afford heteocyclic thioamides in excellent yields.
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spelling pubmed-53020132017-02-22 A novel method for heterocyclic amide–thioamide transformations Fathalla, Walid Ali, Ibrahim A I Pazdera, Pavel Beilstein J Org Chem Full Research Paper In this paper, we introduce a novel and convenient method for the transformation of heterocyclic amides into heteocyclic thioamides. A two-step approach was applied for this transformation: Firstly, we applied a chlorination of the heterocyclic amides to afford the corresponding chloroheterocycles. Secondly, the chloroherocycles and N-cyclohexyl dithiocarbamate cyclohexylammonium salt were heated in chloroform for 12 h at 61 °C to afford heteocyclic thioamides in excellent yields. Beilstein-Institut 2017-01-26 /pmc/articles/PMC5302013/ /pubmed/28228858 http://dx.doi.org/10.3762/bjoc.13.20 Text en Copyright © 2017, Fathalla et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Fathalla, Walid
Ali, Ibrahim A I
Pazdera, Pavel
A novel method for heterocyclic amide–thioamide transformations
title A novel method for heterocyclic amide–thioamide transformations
title_full A novel method for heterocyclic amide–thioamide transformations
title_fullStr A novel method for heterocyclic amide–thioamide transformations
title_full_unstemmed A novel method for heterocyclic amide–thioamide transformations
title_short A novel method for heterocyclic amide–thioamide transformations
title_sort novel method for heterocyclic amide–thioamide transformations
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302013/
https://www.ncbi.nlm.nih.gov/pubmed/28228858
http://dx.doi.org/10.3762/bjoc.13.20
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