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E3 ubiquitin ligase Pirh2 enhances tumorigenic properties of human non-small cell lung carcinoma cells

The product of RCHY1 human gene, Pirh2, is a RING-finger containing E3 ligase that modifies p53 with ubiquitin residues resulting in its subsequent degradation in proteasomes. Transcription of RCHY1 is regulated by p53 itself thus forming a negative regulatory feedback loop. Functionally, by elimina...

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Detalles Bibliográficos
Autores principales:	Daks, Alexandra, Petukhov, Alexey, Fedorova, Olga, Shuvalov, Oleg, Merkulov, Valeriy, Vasileva, Elena, Antonov, Alexey, Barlev, Nikolai A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302039/ https://www.ncbi.nlm.nih.gov/pubmed/28191284 http://dx.doi.org/10.18632/genesandcancer.123

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