An Argonaute phosphorylation cycle promotes microRNA-mediated silencing

MicroRNAs (miRNAs) perform critical functions in normal physiology and disease by associating with Argonaute proteins and downregulating partially complementary messenger RNAs (mRNAs). To identify new regulators of the miRNA pathway, we employed CRISPR-Cas9 genome-wide loss-of-function screening cou...

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Detalles Bibliográficos
Autores principales: Golden, Ryan J., Chen, Beibei, Li, Tuo, Braun, Juliane, Manjunath, Hema, Chen, Xiang, Wu, Jiaxi, Schmid, Vanessa, Chang, Tsung-Cheng, Kopp, Florian, Ramirez-Martinez, Andres, Tagliabracci, Vincent S., Chen, Zhijian J., Xie, Yang, Mendell, Joshua T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302127/
https://www.ncbi.nlm.nih.gov/pubmed/28114302
http://dx.doi.org/10.1038/nature21025

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