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Impact of estrogen receptor α gene and oxytocin receptor gene polymorphisms on female sexuality

Over the past decades, research attention has increasingly been paid to the neurobiological component of sexual behavior. The aim of the present study was to investigate the correlation of estrogen receptor α (ERA) gene polymorphism (rs2234693-PvuII) (T→C substitution) and oxytocin receptor gene pol...

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Autores principales: Armeni, Anastasia K, Assimakopoulos, Konstantinos, Marioli, Dimitra, Koika, Vassiliki, Michaelidou, Euthychia, Mourtzi, Niki, Iconomou, Gregoris, Georgopoulos, Neoklis A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bioscientifica Ltd 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302163/
https://www.ncbi.nlm.nih.gov/pubmed/28069897
http://dx.doi.org/10.1530/EC-16-0090
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author Armeni, Anastasia K
Assimakopoulos, Konstantinos
Marioli, Dimitra
Koika, Vassiliki
Michaelidou, Euthychia
Mourtzi, Niki
Iconomou, Gregoris
Georgopoulos, Neoklis A
author_facet Armeni, Anastasia K
Assimakopoulos, Konstantinos
Marioli, Dimitra
Koika, Vassiliki
Michaelidou, Euthychia
Mourtzi, Niki
Iconomou, Gregoris
Georgopoulos, Neoklis A
author_sort Armeni, Anastasia K
collection PubMed
description Over the past decades, research attention has increasingly been paid to the neurobiological component of sexual behavior. The aim of the present study was to investigate the correlation of estrogen receptor α (ERA) gene polymorphism (rs2234693-PvuII) (T→C substitution) and oxytocin receptor gene polymorphism (rs53576) (G→A substitution) with sexuality parameters of young, healthy women. One hundred thirty-three Greek heterosexual women, students in higher education institutions, 20–25 years of age, sexually active, with normal menstrual cycles (28–35 days), were recruited in the study. Exclusion criteria were chronic and/or major psychiatric diseases, use of oral contraceptive pills (OCs), polycystic ovary syndrome (PCOS), thyroid diseases as well as drugs that are implicated in hypothalamus–pituitary–gonadal axis. T allele (wildtype) of rs2234693 (PvuII) polymorphism of ERA gene was correlated with increased levels of arousal and lubrication, whereas A allele (polymorphic) of rs53576 (OXTR) polymorphism was correlated with increased arousal levels. The simultaneous presence of both T allele of rs2234693 (PvuII) and A allele of rs53576 (OXTR) polymorphisms (T + A group) was correlated with increased arousal, orgasm levels as well as female sexual function index full score. To our knowledge, this is the first study to investigate the interaction between ERA and OXTR with regard to sexual function in women. Female sexuality is a complex behavioral trait that encompasses both biological and psychological components. It seems that variability in female sexual response stems from genetic variability that characterizes endocrine, neurotransmitter and central nervous system influences.
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spelling pubmed-53021632017-03-06 Impact of estrogen receptor α gene and oxytocin receptor gene polymorphisms on female sexuality Armeni, Anastasia K Assimakopoulos, Konstantinos Marioli, Dimitra Koika, Vassiliki Michaelidou, Euthychia Mourtzi, Niki Iconomou, Gregoris Georgopoulos, Neoklis A Endocr Connect Research Over the past decades, research attention has increasingly been paid to the neurobiological component of sexual behavior. The aim of the present study was to investigate the correlation of estrogen receptor α (ERA) gene polymorphism (rs2234693-PvuII) (T→C substitution) and oxytocin receptor gene polymorphism (rs53576) (G→A substitution) with sexuality parameters of young, healthy women. One hundred thirty-three Greek heterosexual women, students in higher education institutions, 20–25 years of age, sexually active, with normal menstrual cycles (28–35 days), were recruited in the study. Exclusion criteria were chronic and/or major psychiatric diseases, use of oral contraceptive pills (OCs), polycystic ovary syndrome (PCOS), thyroid diseases as well as drugs that are implicated in hypothalamus–pituitary–gonadal axis. T allele (wildtype) of rs2234693 (PvuII) polymorphism of ERA gene was correlated with increased levels of arousal and lubrication, whereas A allele (polymorphic) of rs53576 (OXTR) polymorphism was correlated with increased arousal levels. The simultaneous presence of both T allele of rs2234693 (PvuII) and A allele of rs53576 (OXTR) polymorphisms (T + A group) was correlated with increased arousal, orgasm levels as well as female sexual function index full score. To our knowledge, this is the first study to investigate the interaction between ERA and OXTR with regard to sexual function in women. Female sexuality is a complex behavioral trait that encompasses both biological and psychological components. It seems that variability in female sexual response stems from genetic variability that characterizes endocrine, neurotransmitter and central nervous system influences. Bioscientifica Ltd 2017-01-09 /pmc/articles/PMC5302163/ /pubmed/28069897 http://dx.doi.org/10.1530/EC-16-0090 Text en © 2017 The authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License (http://creativecommons.org/licenses/by-nc-nd/4.0/) .
spellingShingle Research
Armeni, Anastasia K
Assimakopoulos, Konstantinos
Marioli, Dimitra
Koika, Vassiliki
Michaelidou, Euthychia
Mourtzi, Niki
Iconomou, Gregoris
Georgopoulos, Neoklis A
Impact of estrogen receptor α gene and oxytocin receptor gene polymorphisms on female sexuality
title Impact of estrogen receptor α gene and oxytocin receptor gene polymorphisms on female sexuality
title_full Impact of estrogen receptor α gene and oxytocin receptor gene polymorphisms on female sexuality
title_fullStr Impact of estrogen receptor α gene and oxytocin receptor gene polymorphisms on female sexuality
title_full_unstemmed Impact of estrogen receptor α gene and oxytocin receptor gene polymorphisms on female sexuality
title_short Impact of estrogen receptor α gene and oxytocin receptor gene polymorphisms on female sexuality
title_sort impact of estrogen receptor α gene and oxytocin receptor gene polymorphisms on female sexuality
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302163/
https://www.ncbi.nlm.nih.gov/pubmed/28069897
http://dx.doi.org/10.1530/EC-16-0090
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