Cargando…

A Prospective Randomized Double-Blind Study Evaluating UP165 and S-Adenosyl-l-Methionine on Depression, Anxiety and Psychological Well-Being

The primary objective of this pilot clinical trial was to evaluate the effects of UP165 (derived from Zea mays L., commonly known as corn) over time. The secondary objective was the comparison for outcomes versus S-adenosyl-methionine (SAM-e). Subjects with mild depression or anxiety were given the...

Descripción completa

Detalles Bibliográficos
Autores principales: Kalman, Douglas S., Feldman, Samantha, Rivas Vazquez, Rafeal, Krieger, Diane R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302331/
https://www.ncbi.nlm.nih.gov/pubmed/28231193
http://dx.doi.org/10.3390/foods4020130
_version_ 1782506520083169280
author Kalman, Douglas S.
Feldman, Samantha
Rivas Vazquez, Rafeal
Krieger, Diane R.
author_facet Kalman, Douglas S.
Feldman, Samantha
Rivas Vazquez, Rafeal
Krieger, Diane R.
author_sort Kalman, Douglas S.
collection PubMed
description The primary objective of this pilot clinical trial was to evaluate the effects of UP165 (derived from Zea mays L., commonly known as corn) over time. The secondary objective was the comparison for outcomes versus S-adenosyl-methionine (SAM-e). Subjects with mild depression or anxiety were given the Beck Depression Inventory second edition (BDI-II), the Beck Anxiety Inventory (BAI), and the Schwartz Outcome Scale (SOS-10). Forty-two subjects (21–65 years old) were randomized to eight-weeks of supplementation with UP165 or SAM-e with questionnaires being administered at randomization, week four and eight. Those receiving UP165 achieved significant reduction from baseline at weeks four and eight, respectively for the BDI-II, as well as a trend for reduction in BAI at week four and significance at week eight. There was a trend for improvement on the SOS at week four and significance at week eight. SAM-e demonstrated a trend for improvement on the BDI-II by week eight over the UP165 with no differences between the two for the BAI or the SOS. Overall, this study indicates that there may be benefit to UP165 for mood enhancement in those with mild depression or anxiety. Randomized placebo comparator trials appear warranted.
format Online
Article
Text
id pubmed-5302331
institution National Center for Biotechnology Information
language English
publishDate 2015
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-53023312017-02-15 A Prospective Randomized Double-Blind Study Evaluating UP165 and S-Adenosyl-l-Methionine on Depression, Anxiety and Psychological Well-Being Kalman, Douglas S. Feldman, Samantha Rivas Vazquez, Rafeal Krieger, Diane R. Foods Article The primary objective of this pilot clinical trial was to evaluate the effects of UP165 (derived from Zea mays L., commonly known as corn) over time. The secondary objective was the comparison for outcomes versus S-adenosyl-methionine (SAM-e). Subjects with mild depression or anxiety were given the Beck Depression Inventory second edition (BDI-II), the Beck Anxiety Inventory (BAI), and the Schwartz Outcome Scale (SOS-10). Forty-two subjects (21–65 years old) were randomized to eight-weeks of supplementation with UP165 or SAM-e with questionnaires being administered at randomization, week four and eight. Those receiving UP165 achieved significant reduction from baseline at weeks four and eight, respectively for the BDI-II, as well as a trend for reduction in BAI at week four and significance at week eight. There was a trend for improvement on the SOS at week four and significance at week eight. SAM-e demonstrated a trend for improvement on the BDI-II by week eight over the UP165 with no differences between the two for the BAI or the SOS. Overall, this study indicates that there may be benefit to UP165 for mood enhancement in those with mild depression or anxiety. Randomized placebo comparator trials appear warranted. MDPI 2015-05-08 /pmc/articles/PMC5302331/ /pubmed/28231193 http://dx.doi.org/10.3390/foods4020130 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kalman, Douglas S.
Feldman, Samantha
Rivas Vazquez, Rafeal
Krieger, Diane R.
A Prospective Randomized Double-Blind Study Evaluating UP165 and S-Adenosyl-l-Methionine on Depression, Anxiety and Psychological Well-Being
title A Prospective Randomized Double-Blind Study Evaluating UP165 and S-Adenosyl-l-Methionine on Depression, Anxiety and Psychological Well-Being
title_full A Prospective Randomized Double-Blind Study Evaluating UP165 and S-Adenosyl-l-Methionine on Depression, Anxiety and Psychological Well-Being
title_fullStr A Prospective Randomized Double-Blind Study Evaluating UP165 and S-Adenosyl-l-Methionine on Depression, Anxiety and Psychological Well-Being
title_full_unstemmed A Prospective Randomized Double-Blind Study Evaluating UP165 and S-Adenosyl-l-Methionine on Depression, Anxiety and Psychological Well-Being
title_short A Prospective Randomized Double-Blind Study Evaluating UP165 and S-Adenosyl-l-Methionine on Depression, Anxiety and Psychological Well-Being
title_sort prospective randomized double-blind study evaluating up165 and s-adenosyl-l-methionine on depression, anxiety and psychological well-being
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302331/
https://www.ncbi.nlm.nih.gov/pubmed/28231193
http://dx.doi.org/10.3390/foods4020130
work_keys_str_mv AT kalmandouglass aprospectiverandomizeddoubleblindstudyevaluatingup165andsadenosyllmethionineondepressionanxietyandpsychologicalwellbeing
AT feldmansamantha aprospectiverandomizeddoubleblindstudyevaluatingup165andsadenosyllmethionineondepressionanxietyandpsychologicalwellbeing
AT rivasvazquezrafeal aprospectiverandomizeddoubleblindstudyevaluatingup165andsadenosyllmethionineondepressionanxietyandpsychologicalwellbeing
AT kriegerdianer aprospectiverandomizeddoubleblindstudyevaluatingup165andsadenosyllmethionineondepressionanxietyandpsychologicalwellbeing
AT kalmandouglass prospectiverandomizeddoubleblindstudyevaluatingup165andsadenosyllmethionineondepressionanxietyandpsychologicalwellbeing
AT feldmansamantha prospectiverandomizeddoubleblindstudyevaluatingup165andsadenosyllmethionineondepressionanxietyandpsychologicalwellbeing
AT rivasvazquezrafeal prospectiverandomizeddoubleblindstudyevaluatingup165andsadenosyllmethionineondepressionanxietyandpsychologicalwellbeing
AT kriegerdianer prospectiverandomizeddoubleblindstudyevaluatingup165andsadenosyllmethionineondepressionanxietyandpsychologicalwellbeing