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Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform

Development of new drug regimens that allow rapid, sterilizing treatment of tuberculosis has been limited by the complexity and time required for genetic manipulations in Mycobacterium tuberculosis. CRISPR interference (CRISPRi) promises to be a robust, easily engineered, and scalable platform for r...

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Detalles Bibliográficos
Autores principales:	Rock, Jeremy M., Hopkins, Forrest F., Chavez, Alejandro, Diallo, Marieme, Chase, Michael R., Gerrick, Elias R., Pritchard, Justin R., Church, George M., Rubin, Eric J., Sassetti, Christopher M., Schnappinger, Dirk, Fortune, Sarah M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2017
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302332/ https://www.ncbi.nlm.nih.gov/pubmed/28165460 http://dx.doi.org/10.1038/nmicrobiol.2016.274

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