A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold Nanoparticles

In this paper, highly purified and stable gold nanoparticle (AuNP) dimers connected at the two ends of DNA linkage were prepared by a versatile method. A nanostructured, surface-enhanced Raman scattering (SERS) switching sensor system was fabricated based on the controlled organization of gold nanop...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Yansheng, Cheng, Yaya, Xu, Liping, Du, Hongwu, Zhang, Peixun, Wen, Yongqiang, Zhang, Xueji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302489/
https://www.ncbi.nlm.nih.gov/pubmed/28344281
http://dx.doi.org/10.3390/nano6020024
_version_ 1782506553833684992
author Li, Yansheng
Cheng, Yaya
Xu, Liping
Du, Hongwu
Zhang, Peixun
Wen, Yongqiang
Zhang, Xueji
author_facet Li, Yansheng
Cheng, Yaya
Xu, Liping
Du, Hongwu
Zhang, Peixun
Wen, Yongqiang
Zhang, Xueji
author_sort Li, Yansheng
collection PubMed
description In this paper, highly purified and stable gold nanoparticle (AuNP) dimers connected at the two ends of DNA linkage were prepared by a versatile method. A nanostructured, surface-enhanced Raman scattering (SERS) switching sensor system was fabricated based on the controlled organization of gold nanoparticles (AuNPs) by a DNA nanomachine through the controlled formation/deformation of SERS “hotspots”. This strategy not only opens opportunities in the precise engineering of gap distances in gold-gold nanostructures in a highly controllable and reproducible fashion, but also provides a unique ability to research the origin of SERS and sequence-specific DNA detection.
format Online
Article
Text
id pubmed-5302489
institution National Center for Biotechnology Information
language English
publishDate 2016
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-53024892017-03-21 A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold Nanoparticles Li, Yansheng Cheng, Yaya Xu, Liping Du, Hongwu Zhang, Peixun Wen, Yongqiang Zhang, Xueji Nanomaterials (Basel) Article In this paper, highly purified and stable gold nanoparticle (AuNP) dimers connected at the two ends of DNA linkage were prepared by a versatile method. A nanostructured, surface-enhanced Raman scattering (SERS) switching sensor system was fabricated based on the controlled organization of gold nanoparticles (AuNPs) by a DNA nanomachine through the controlled formation/deformation of SERS “hotspots”. This strategy not only opens opportunities in the precise engineering of gap distances in gold-gold nanostructures in a highly controllable and reproducible fashion, but also provides a unique ability to research the origin of SERS and sequence-specific DNA detection. MDPI 2016-01-22 /pmc/articles/PMC5302489/ /pubmed/28344281 http://dx.doi.org/10.3390/nano6020024 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Yansheng
Cheng, Yaya
Xu, Liping
Du, Hongwu
Zhang, Peixun
Wen, Yongqiang
Zhang, Xueji
A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold Nanoparticles
title A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold Nanoparticles
title_full A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold Nanoparticles
title_fullStr A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold Nanoparticles
title_full_unstemmed A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold Nanoparticles
title_short A Nanostructured SERS Switch Based on Molecular Beacon-Controlled Assembly of Gold Nanoparticles
title_sort nanostructured sers switch based on molecular beacon-controlled assembly of gold nanoparticles
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302489/
https://www.ncbi.nlm.nih.gov/pubmed/28344281
http://dx.doi.org/10.3390/nano6020024
work_keys_str_mv AT liyansheng ananostructuredsersswitchbasedonmolecularbeaconcontrolledassemblyofgoldnanoparticles
AT chengyaya ananostructuredsersswitchbasedonmolecularbeaconcontrolledassemblyofgoldnanoparticles
AT xuliping ananostructuredsersswitchbasedonmolecularbeaconcontrolledassemblyofgoldnanoparticles
AT duhongwu ananostructuredsersswitchbasedonmolecularbeaconcontrolledassemblyofgoldnanoparticles
AT zhangpeixun ananostructuredsersswitchbasedonmolecularbeaconcontrolledassemblyofgoldnanoparticles
AT wenyongqiang ananostructuredsersswitchbasedonmolecularbeaconcontrolledassemblyofgoldnanoparticles
AT zhangxueji ananostructuredsersswitchbasedonmolecularbeaconcontrolledassemblyofgoldnanoparticles
AT liyansheng nanostructuredsersswitchbasedonmolecularbeaconcontrolledassemblyofgoldnanoparticles
AT chengyaya nanostructuredsersswitchbasedonmolecularbeaconcontrolledassemblyofgoldnanoparticles
AT xuliping nanostructuredsersswitchbasedonmolecularbeaconcontrolledassemblyofgoldnanoparticles
AT duhongwu nanostructuredsersswitchbasedonmolecularbeaconcontrolledassemblyofgoldnanoparticles
AT zhangpeixun nanostructuredsersswitchbasedonmolecularbeaconcontrolledassemblyofgoldnanoparticles
AT wenyongqiang nanostructuredsersswitchbasedonmolecularbeaconcontrolledassemblyofgoldnanoparticles
AT zhangxueji nanostructuredsersswitchbasedonmolecularbeaconcontrolledassemblyofgoldnanoparticles

Ejemplares similares