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Formation and Controlled Drug Release Using a Three-Component Supramolecular Hydrogel for Anti-Schistosoma Japonicum Cercariae

A novel three-component supramolecular hydrogel based on riboflavin, melamine and amino acid derivatives were constructed for controlled release of pesticides, Niclosamide derivatives. The formation of hydrogel may be attributed to self-assemble via hydrogen bonding and π–π interaction, which have b...

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Detalles Bibliográficos
Autores principales: Li, Yibao, Zhu, Lei, Fan, Yulan, Li, Yayun, Cheng, Linxiu, Liu, Wei, Li, Xun, Fan, Xiaolin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302511/
https://www.ncbi.nlm.nih.gov/pubmed/28344302
http://dx.doi.org/10.3390/nano6030046
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author Li, Yibao
Zhu, Lei
Fan, Yulan
Li, Yayun
Cheng, Linxiu
Liu, Wei
Li, Xun
Fan, Xiaolin
author_facet Li, Yibao
Zhu, Lei
Fan, Yulan
Li, Yayun
Cheng, Linxiu
Liu, Wei
Li, Xun
Fan, Xiaolin
author_sort Li, Yibao
collection PubMed
description A novel three-component supramolecular hydrogel based on riboflavin, melamine and amino acid derivatives were constructed for controlled release of pesticides, Niclosamide derivatives. The formation of hydrogel may be attributed to self-assemble via hydrogen bonding and π–π interaction, which have been researched via scanning electron microscopy (SEM) and Fourier transform infrared (FT-IR) spectra. The rheological experiments showed that the hydrogel materials and drug-loaded hydrogel all demonstrated good mechanical strength and high stability. Further experimental results indicated that the drug-loaded hydrogels show large drug loadings, long-term release time and relatively higher efficiency to anti-cercariae in the water environment.
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spelling pubmed-53025112017-03-21 Formation and Controlled Drug Release Using a Three-Component Supramolecular Hydrogel for Anti-Schistosoma Japonicum Cercariae Li, Yibao Zhu, Lei Fan, Yulan Li, Yayun Cheng, Linxiu Liu, Wei Li, Xun Fan, Xiaolin Nanomaterials (Basel) Article A novel three-component supramolecular hydrogel based on riboflavin, melamine and amino acid derivatives were constructed for controlled release of pesticides, Niclosamide derivatives. The formation of hydrogel may be attributed to self-assemble via hydrogen bonding and π–π interaction, which have been researched via scanning electron microscopy (SEM) and Fourier transform infrared (FT-IR) spectra. The rheological experiments showed that the hydrogel materials and drug-loaded hydrogel all demonstrated good mechanical strength and high stability. Further experimental results indicated that the drug-loaded hydrogels show large drug loadings, long-term release time and relatively higher efficiency to anti-cercariae in the water environment. MDPI 2016-03-09 /pmc/articles/PMC5302511/ /pubmed/28344302 http://dx.doi.org/10.3390/nano6030046 Text en © 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons by Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Li, Yibao
Zhu, Lei
Fan, Yulan
Li, Yayun
Cheng, Linxiu
Liu, Wei
Li, Xun
Fan, Xiaolin
Formation and Controlled Drug Release Using a Three-Component Supramolecular Hydrogel for Anti-Schistosoma Japonicum Cercariae
title Formation and Controlled Drug Release Using a Three-Component Supramolecular Hydrogel for Anti-Schistosoma Japonicum Cercariae
title_full Formation and Controlled Drug Release Using a Three-Component Supramolecular Hydrogel for Anti-Schistosoma Japonicum Cercariae
title_fullStr Formation and Controlled Drug Release Using a Three-Component Supramolecular Hydrogel for Anti-Schistosoma Japonicum Cercariae
title_full_unstemmed Formation and Controlled Drug Release Using a Three-Component Supramolecular Hydrogel for Anti-Schistosoma Japonicum Cercariae
title_short Formation and Controlled Drug Release Using a Three-Component Supramolecular Hydrogel for Anti-Schistosoma Japonicum Cercariae
title_sort formation and controlled drug release using a three-component supramolecular hydrogel for anti-schistosoma japonicum cercariae
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302511/
https://www.ncbi.nlm.nih.gov/pubmed/28344302
http://dx.doi.org/10.3390/nano6030046
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