Widespread GLI expression but limited canonical hedgehog signaling restricted to the ductular reaction in human chronic liver disease

Canonical Hedgehog (Hh) signaling in vertebrate cells occurs following Smoothened activation/translocation into the primary cilia (Pc), followed by a GLI transcriptional response. Nonetheless, GLI activation can occur independently of the canonical Hh pathway. Using a murine model of liver injury, w...

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Detalles Bibliográficos
Autores principales: Grzelak, Candice Alexandra, Sigglekow, Nicholas David, Tirnitz-Parker, Janina Elke Eleonore, Hamson, Elizabeth Jane, Warren, Alessandra, Maneck, Bharvi, Chen, Jinbiao, Patkunanathan, Bramilla, Boland, Jade, Cheng, Robert, Shackel, Nicholas Adam, Seth, Devanshi, Bowen, David Geoffrey, Martelotto, Luciano Gastón, Watkins, D. Neil, McCaughan, Geoffrey William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302813/
https://www.ncbi.nlm.nih.gov/pubmed/28187190
http://dx.doi.org/10.1371/journal.pone.0171480

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