The in vitro and vivo anti-tumor effects and molecular mechanisms of suberoylanilide hydroxamic acid (SAHA) and MG132 on the aggressive phenotypes of gastric cancer cells

Here, we found that both SAHA and MG132 synergistically inhibited proliferation, glycolysis and mitochondrial oxidization, induced cell cycle arrest and apoptosis in MGC-803 and MKN28 cells. SAHA increased cell migration and invasionat a low concentration. SAHA induced the overexpression of acetyl h...

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Detalles Bibliográficos
Autores principales: Lu, Hang, Yang, Xue-feng, Tian, Xiao-qing, Tang, Shou-long, Li, Lian-qian, Zhao, Shuang, Zheng, Hua-chuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302865/
https://www.ncbi.nlm.nih.gov/pubmed/27447743
http://dx.doi.org/10.18632/oncotarget.10643

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302865/
https://www.ncbi.nlm.nih.gov/pubmed/27447743
http://dx.doi.org/10.18632/oncotarget.10643

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