Cargando…

The challenges of replication

Interpreting the first results from the Reproducibility Project: Cancer Biology requires a highly nuanced approach.

Detalles Bibliográficos
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2017
Materias:	Cancer Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302882/ https://www.ncbi.nlm.nih.gov/pubmed/28182866 http://dx.doi.org/10.7554/eLife.23693

Ejemplares similares

Challenges for assessing replicability in preclinical cancer biology
por: Errington, Timothy M, et al.
Publicado: (2021)

Making sense of replications
por: Nosek, Brian A, et al.
Publicado: (2017)

Investigating the replicability of preclinical cancer biology
por: Errington, Timothy M, et al.
Publicado: (2021)

Replication Study: Fusobacterium nucleatum infection is prevalent in human colorectal carcinoma
por: Repass, John
Publicado: (2018)

Replication Study: Transcriptional amplification in tumor cells with elevated c-Myc
por: Lewis, L Michelle, et al.
Publicado: (2018)

Replication Study: Intestinal inflammation targets cancer-inducing activity of the microbiota
por: Eaton, Kathryn, et al.
Publicado: (2018)

Replication Study: Melanoma genome sequencing reveals frequent PREX2 mutations
por: Horrigan, Stephen K, et al.
Publicado: (2017)

Replication Study: Systematic identification of genomic markers of drug sensitivity in cancer cells
por: Vanden Heuvel, John P, et al.
Publicado: (2018)

Replication Study: Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs
por: Mantis, Christine, et al.
Publicado: (2017)

Replication Study: BET bromodomain inhibition as a therapeutic strategy to target c-Myc
por: Aird, Fraser, et al.
Publicado: (2017)

53BP1 and BRCA1 control pathway choice for stalled replication restart
por: Xu, Yixi, et al.
Publicado: (2017)

Replication Study: Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia
por: Shan, Xiaochuan, et al.
Publicado: (2017)

Replication Study: Wnt activity defines colon cancer stem cells and is regulated by the microenvironment
por: Essex, Anthony, et al.
Publicado: (2019)

Replication Study: Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs
por: Wang, Hongyan, et al.
Publicado: (2020)

Replication Study: Biomechanical remodeling of the microenvironment by stromal caveolin-1 favors tumor invasion and metastasis
por: Sheen, Mee Rie, et al.
Publicado: (2019)

Replication Study: Discovery and preclinical validation of drug indications using compendia of public gene expression data
por: Kandela, Irawati, et al.
Publicado: (2017)

Replication Study: A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
por: Kerwin, John, et al.
Publicado: (2020)

Protection of nascent DNA at stalled replication forks is mediated by phosphorylation of RIF1 intrinsically disordered region
por: Balasubramanian, Sandhya, et al.
Publicado: (2022)

Loss of p53 suppresses replication-stress-induced DNA breakage in G1/S checkpoint deficient cells
por: Benedict, Bente, et al.
Publicado: (2018)

Replication Study: The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors
por: Horrigan, Stephen K
Publicado: (2017)

Replication Study: Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
por: Kim, Jeewon, et al.
Publicado: (2018)

Challenges in validating candidate therapeutic targets in cancer
por: Settleman, Jeffrey, et al.
Publicado: (2018)

Replication Study: The microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
por: Yan, Xuefei, et al.
Publicado: (2019)

Checkpoint blockade‐based immunotherapy in the context of tumor microenvironment: Opportunities and challenges
por: Duan, Jingjing, et al.
Publicado: (2018)

Implications of ubiquitination and the maintenance of replication fork stability in cancer therapy
por: Xia, Donghui, et al.
Publicado: (2023)

Mutation of the RelA(p65) Thr505 phosphosite disrupts the DNA replication stress response leading to CHK1 inhibitor resistance
por: Hunter, Jill E., et al.
Publicado: (2022)

Myogenic regulatory transcription factors regulate growth in rhabdomyosarcoma
por: Tenente, Inês M, et al.
Publicado: (2017)

NADPH oxidase-mediated redox signaling promotes oxidative stress resistance and longevity through memo-1 in C. elegans
por: Ewald, Collin Yvès, et al.
Publicado: (2017)

Autophagy inhibition overcomes multiple mechanisms of resistance to BRAF inhibition in brain tumors
por: Mulcahy Levy, Jean M, et al.
Publicado: (2017)

Correction: TP53 exon-6 truncating mutations produce separation of function isoforms with pro-tumorigenic functions
por: Shirole, Nitin H, et al.
Publicado: (2017)

Matrix-regulated integrin α(v)β(5) maintains α(5)β(1)-dependent desmoplastic traits prognostic of neoplastic recurrence
por: Franco-Barraza, Janusz, et al.
Publicado: (2017)

Mitochondrial respiratory gene expression is suppressed in many cancers
por: Reznik, Ed, et al.
Publicado: (2017)

Melanoma mystery
por: Davis, Roger J
Publicado: (2017)

Mixed outcomes for computational predictions
por: Dang, Chi Van
Publicado: (2017)

Small molecules remain on target for c-Myc
por: Sun, Linchong, et al.
Publicado: (2017)

BRAF(V600E) cooperates with CDX2 inactivation to promote serrated colorectal tumorigenesis
por: Sakamoto, Naoya, et al.
Publicado: (2017)

Characterization of Tumor Cells Using a Medical Wire for Capturing Circulating Tumor Cells: A 3D Approach Based on Immunofluorescence and DNA FISH
por: Gallerani, Giulia, et al.
Publicado: (2017)

Jak2-mediated phosphorylation of Atoh1 is critical for medulloblastoma growth
por: Klisch, Tiemo J, et al.
Publicado: (2017)

Intake of dietary fibre and lifetime non-steroidal anti-inflammatory drug (NSAID) use and the incidence of colorectal polyps in a population screened for colorectal cancer
por: Shaw, Eileen, et al.
Publicado: (2017)

Correction: KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer
por: Krall, Elsa Beyer, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_g62dbadf7mnv1h4vkahnbctsfs