Immortalization of human AE pre-leukemia cells by hTERT allows leukemic transformation

Human CD34+ hematopoietic stem and progenitor cells (HSPC) expressing fusion protein AML1-ETO (AE), generated by the t(8;21)(q22;q22) rearrangement, manifest enhanced self-renewal and dysregulated differentiation without leukemic transformation, representing a pre-leukemia stage. Enabling replicativ...

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Detalles Bibliográficos
Autores principales: Lin, Shan, Wei, Junping, Wunderlich, Mark, Chou, Fu-Sheng, Mulloy, James C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302887/
https://www.ncbi.nlm.nih.gov/pubmed/27509060
http://dx.doi.org/10.18632/oncotarget.11093

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302887/
https://www.ncbi.nlm.nih.gov/pubmed/27509060
http://dx.doi.org/10.18632/oncotarget.11093

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