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Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of Rhesus macaques during normative aging
Lipidomic analyses of the frontal cortex of Rhesus macaques across three selected age groups (young, sexually-mature, old) revealed that docosahexaenoic acids (DHAs) displayed notable and unique accretions in sexually-mature macaques for all phospholipid classes examined, which were not observable i...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302890/ https://www.ncbi.nlm.nih.gov/pubmed/27517158 http://dx.doi.org/10.18632/oncotarget.11190 |
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author | Lam, Sin Man Chua, Gek Huey Li, Xiao-Jiang Su, Bing Shui, Guanghou |
author_facet | Lam, Sin Man Chua, Gek Huey Li, Xiao-Jiang Su, Bing Shui, Guanghou |
author_sort | Lam, Sin Man |
collection | PubMed |
description | Lipidomic analyses of the frontal cortex of Rhesus macaques across three selected age groups (young, sexually-mature, old) revealed that docosahexaenoic acids (DHAs) displayed notable and unique accretions in sexually-mature macaques for all phospholipid classes examined, which were not observable in all remaining polyunsaturated fatty acids (PUFAs) investigated. On the other hand, arachidonic acid (ARA) exhibited sharp attritions in the membrane lipidomes of sexually-mature macaques, a decline which was attenuated only for cardiolipins (CLs). DHA enrichment in phospholipids was lost in old macaques, with accompanying augmentations in very-long-chain sphingomyelins (VLC-SMs). Age-dependent alterations in membrane lipidomes point to a possibly complex temporal interplay between DHA-enriched membrane microdomains and SM-/cholesterol-rich rafts in neural membranes during normative aging. Lipid co-regulation data revealed an increasingly intense degree of co-regulation between membrane lipid classes with age, and suggest that reduction in CLs during normative brain aging may prompt alternative membrane lipid synthetic pathways driven by a compromised energy availability in the aging brain. |
format | Online Article Text |
id | pubmed-5302890 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53028902017-02-13 Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of Rhesus macaques during normative aging Lam, Sin Man Chua, Gek Huey Li, Xiao-Jiang Su, Bing Shui, Guanghou Oncotarget Research Paper: Gerotarget (Focus on Aging) Lipidomic analyses of the frontal cortex of Rhesus macaques across three selected age groups (young, sexually-mature, old) revealed that docosahexaenoic acids (DHAs) displayed notable and unique accretions in sexually-mature macaques for all phospholipid classes examined, which were not observable in all remaining polyunsaturated fatty acids (PUFAs) investigated. On the other hand, arachidonic acid (ARA) exhibited sharp attritions in the membrane lipidomes of sexually-mature macaques, a decline which was attenuated only for cardiolipins (CLs). DHA enrichment in phospholipids was lost in old macaques, with accompanying augmentations in very-long-chain sphingomyelins (VLC-SMs). Age-dependent alterations in membrane lipidomes point to a possibly complex temporal interplay between DHA-enriched membrane microdomains and SM-/cholesterol-rich rafts in neural membranes during normative aging. Lipid co-regulation data revealed an increasingly intense degree of co-regulation between membrane lipid classes with age, and suggest that reduction in CLs during normative brain aging may prompt alternative membrane lipid synthetic pathways driven by a compromised energy availability in the aging brain. Impact Journals LLC 2016-08-10 /pmc/articles/PMC5302890/ /pubmed/27517158 http://dx.doi.org/10.18632/oncotarget.11190 Text en Copyright: © 2016 Lam et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper: Gerotarget (Focus on Aging) Lam, Sin Man Chua, Gek Huey Li, Xiao-Jiang Su, Bing Shui, Guanghou Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of Rhesus macaques during normative aging |
title | Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of Rhesus macaques during normative aging |
title_full | Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of Rhesus macaques during normative aging |
title_fullStr | Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of Rhesus macaques during normative aging |
title_full_unstemmed | Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of Rhesus macaques during normative aging |
title_short | Biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of Rhesus macaques during normative aging |
title_sort | biological relevance of fatty acyl heterogeneity to the neural membrane dynamics of rhesus macaques during normative aging |
topic | Research Paper: Gerotarget (Focus on Aging) |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5302890/ https://www.ncbi.nlm.nih.gov/pubmed/27517158 http://dx.doi.org/10.18632/oncotarget.11190 |
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